Shenling Baizhu Powder Alleviates TNBS-Induced Colitis in Rats by Improving Intestinal Epithelial Permeability and Inhibiting Inflammation Through the TLR5/MyD88/NF-κB Pathway
机构：[1]Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou, Peoples R China广东省中医院[2]Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China广东省中医院[3]Guangdong Prov Key Lab Clin Res Tradit Chinese Med, Guangzhou, Peoples R China广东省中医院[4]Guangzhou Univ Chinese Med, State Key Lab Dampness Syndrome Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China广东省中医院[5]Guangdong Hong Kong Macau Joint Lab Chinese Med &, Hong Kong, Guangdong, Peoples R China[6]Collaborat Innovat Team Tradit Chinese Med Prevent, Guangzhou, Peoples R China[7]Dongguan Hosp Guangzhou Univ Chinese Med, Dongguan, Peoples R China
Aim of the study: To evaluate the protective effect and mechanism of shenling baizhu powder (SBP) on TNBS-induced colitis.Methods: Rats were given TNBS to establish the model of colitis and subsequently treated with different doses of SBP or mesalamine (MES). In addition, the expression of the TLR5/MyD88/NF-kappa B signaling pathway and critical targets of the intestinal mucosal barrier was detected by immunochemical analysis techniques.Results: SBP significantly ameliorated the symptoms of TNBS-induced colitis in rats and reduced the secretion of pro-inflammatory cytokines. SBP could effectively strengthen epithelial barrier integrity in TNBS-induced colitis by increasing the secretion of mucin and tight junction and inhibiting apoptosis. Furthermore, we identified the crucial role of the TLR5/MyD88/NF-kappa B signaling pathway in exerting the therapeutic effect of SBP.Conclusion: The results of our study suggest that SBP has therapeutic effects on TNBS-induced colitis and potential value in treating and maintaining remission of colitis.
基金：
National Natural Science Foundation of China [82174318]; 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund (Guangdong-Hong Kong-Macau Joint Lab) [2020B1212030006]; Natural Science Foundation of Guangdong [2021A1515011498]; special project of the State Key Laboratory of Dampness Syndrome of Chinese Medicine [SZ2021ZZ13, SZ2021ZZ25, SZ2021ZZ44, SZ2021ZZ02]; Special Project for Research and Development in Key areas of Guangdong Province [2020B1111100010]
第一作者机构：[1]Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[2]Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China[3]Guangdong Prov Key Lab Clin Res Tradit Chinese Med, Guangzhou, Peoples R China[4]Guangzhou Univ Chinese Med, State Key Lab Dampness Syndrome Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China[5]Guangdong Hong Kong Macau Joint Lab Chinese Med &, Hong Kong, Guangdong, Peoples R China[6]Collaborat Innovat Team Tradit Chinese Med Prevent, Guangzhou, Peoples R China[7]Dongguan Hosp Guangzhou Univ Chinese Med, Dongguan, Peoples R China
推荐引用方式(GB/T 7714)：
Rao Kehan,Qin Shumin,Yang Yuanming,et al.Shenling Baizhu Powder Alleviates TNBS-Induced Colitis in Rats by Improving Intestinal Epithelial Permeability and Inhibiting Inflammation Through the TLR5/MyD88/NF-κB Pathway[J].FRONTIERS IN PHARMACOLOGY.2022,13:doi:10.3389/fphar.2022.883918.
APA：
Rao, Kehan,Qin, Shumin,Yang, Yuanming,Zhan, Kai,Wu, Haomeng...&Huang, Shaogang.(2022).Shenling Baizhu Powder Alleviates TNBS-Induced Colitis in Rats by Improving Intestinal Epithelial Permeability and Inhibiting Inflammation Through the TLR5/MyD88/NF-κB Pathway.FRONTIERS IN PHARMACOLOGY,13,
MLA：
Rao, Kehan,et al."Shenling Baizhu Powder Alleviates TNBS-Induced Colitis in Rats by Improving Intestinal Epithelial Permeability and Inhibiting Inflammation Through the TLR5/MyD88/NF-κB Pathway".FRONTIERS IN PHARMACOLOGY 13.(2022)
医学