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Tremella fuciformis polysaccharides ameliorated ulcerative colitis via inhibiting inflammation and enhancing intestinal epithelial barrier function.

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资源类型：
Pubmed体系：
作者：
Xiao Hongyu[a] * ; Li Hailun[c] * ; Wen Yifan[a] ; Jiang Dongxu[a] ; Zhu Shumin[a] ; He Xueling[a] ; Xiong Qingping[a] ; Gao Jie[a] ; Hou Shaozhen[a] ; Huang Song[a] ; He Lian[b,*1] ; Liang Jian[a,*2] ;
机构： [a]School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [b]Guangdong Food and Drug Vocational College, Guangzhou, Guangdong 510520, PR China [c]Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223002, Jiangsu, PR China
出处：
DOI： 10.1016/j.ijbiomac.2021.03.083
ISSN：

关键词： Tremella fuciformis polysaccharides Ulcerative colitis Inflammation and intestinal barrier

摘要：
The purpose of this paper was to explore the therapeutic effect and underlying mechanism of Tremella fuciformis polysaccharides (TFP) on ulcerative colitis (UC) based on dextran sodium sulfate (DSS)-induced mice UC model and lipopolysaccharide (LPS)-stimulated Caco-2 cells model. The results firstly indicated that TFP can significantly alleviate the symptoms and signs of the DSS-induced mice UC model, which manifests as improvement of body weight loss, increase of colon length, decrease of colon thickness and reduction of intestinal permeability. Then, results from histopathological and electron microscope analysis further implied that TFP could dramatically reduce inflammatory cells infiltration and restore intestinal epithelial barrier integrity. In addition, the experiments of LPS-stimulated Caco-2 cells model in vitro also further confirmed that TFP could markedly inhibit the expressions of pro-inflammatory cytokines and increase related genes or proteins expressions of intestinal barrier and mucus barrier. Taken together, these data suggested that TFP has a significant therapeutic effect on DSS-induced UC model, and its mechanisms are closely linked to the inhibition of inflammation and the restoration of intestinal barrier and mucus barrier function. These beneficial effects may make TFP a promising drug to be used in alleviating UC. Copyright © 2021. Published by Elsevier B.V.

基金：
National Natural Science Foundation of China (No. 82004025). Guangdong Province Universities and Colleges the Special Funds from Central Finance of China in Support of the Development of Local Colleges and University (No. A1-AFD018201Z0348). National Engineering Research Center for Modernization of Traditional Chinese Medicine (2017B030314096). Foundation and Applied Basic Research Fund project of Guangdong Province (2019A1515110561, 2019A1515110653). The Projects of Guangzhou University of Chinese Medicine (A3-0402-20-415-005, A1-AFD018201Z1020). Natural Science Foundation of Guangdong Province China (No.2019A1515012082). The project of Education Department of Guangdong Province (No.2019KTSCX026). Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research (LPRK201903).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 化学
小类 | 2 区 生化与分子生物学 2 区 应用化学 2 区 高分子科学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 应用化学 2 区 高分子科学
第一作者：
第一作者机构： [a]School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China
共同第一作者：
通讯作者：
通讯机构： [a]School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [b]Guangdong Food and Drug Vocational College, Guangzhou, Guangdong 510520, PR China [*1]Guangdong Food and Drug Vocational College, Guangzhou, Guangdong 510520, PR China. [*2]Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China.
推荐引用方式(GB/T 7714)：
Xiao Hongyu,Li Hailun,Wen Yifan,et al.Tremella fuciformis polysaccharides ameliorated ulcerative colitis via inhibiting inflammation and enhancing intestinal epithelial barrier function.[J].International journal of biological macromolecules.2021,180:633-642.doi:10.1016/j.ijbiomac.2021.03.083.
APA：
Xiao Hongyu,Li Hailun,Wen Yifan,Jiang Dongxu,Zhu Shumin...&Liang Jian.(2021).Tremella fuciformis polysaccharides ameliorated ulcerative colitis via inhibiting inflammation and enhancing intestinal epithelial barrier function..International journal of biological macromolecules,180,
MLA：
Xiao Hongyu,et al."Tremella fuciformis polysaccharides ameliorated ulcerative colitis via inhibiting inflammation and enhancing intestinal epithelial barrier function.".International journal of biological macromolecules 180.(2021):633-642

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