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Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice.

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文献详情

资源类型：
Pubmed体系：
作者：
Huang Sha[1] * ; Wang Yuhua[1] * ; Xie Shuwen[1] ; Lai Yuqi[1] ; Mo Chan[2] ; Zeng Ting[1] ; Kuang Shanshan[1] ; Zhou Chuying[1] ; Zeng Zhiyun[1] ; Chen Yuyao[1] ; Huang Shaohui[1] ; Gao Lei[1,3,4] ; Lv Zhiping[1] ;
机构： [1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong,510515, China [2]Medical Laboratory of the Third affiliated Hospital of Shenzhen University, Shenzhen, 518001, China [3]The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China [4]Guangdong Provincial Key Laboratory of Shock and Microcirculation, Southern Medical University, Guangzhou, 510515, China
出处：
DOI： 10.1016/j.phymed.2022.154117
ISSN：

关键词： Ferroptosis Cav-1 ROS Liver fibrosis Hepatic stellate cells Isoliquiritigenin

摘要：
Liver fibrosis is a major disease that threatens people's health around the world. However, there is a lack of effective treatment to completely reverse liver fibrosis. Liver transplantation is currently the only curative option for patients with advanced cirrhosis. Ferroptosis is a newly discovered type of cell death and plays an important role in the process of liver fibrosis, but the specific mechanism needs to be clarified.To explore the regulatory mechanism of isoliquiritigenin (ISL) in the process of liver fibrosis and the relationship between Cav-1 and ferroptosis.In this research, zebrafish, HSC-T6 cells, and mice were used as the research object. Different ROS probes to visually detect the content and distribution of ROS in live zebrafish and cells. Lentivirus and siRNA-mediated transfection techniques were used for the construction of Cav-1 overexpression and knockdown cell lines to verify the important role of Cav-1 in vitro.Generally, we first elucidated that ISL relieved liver fibrosis by inducing hepatic stellate cells (HSCs) ferroptosis through repressing GPX4 expression and increasing the expression of TFR and DMT1, thus producing a large number of ROS, we also found that Cav-1 exerted its anti-hepatic fibrosis effect by promoting HSCs ferroptosis.Our results have shown that Cav-1-mediated HSCs ferroptosis is necessary for ISL to play an anti-fibrotic effect in vitro and in vivo.Copyright © 2022 Elsevier GmbH. All rights reserved.

基金：
The project was financially supported by the National Natural Science Foundation of China (82174168, 81774170, and 82074131), the Natural Science Foundation of Guangdong Province (2018B030306012, 2021A1515011667), the Scientific Research Initiative Program of Southern Medical University (CX2017N001), and the Guangming District Economic Development Special Fund (2021R01075, 2020R01126).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 2 区 医学
小类 | 1 区 植物科学 1 区 全科医学与补充医学 1 区 药学 2 区 药物化学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 药物化学 1 区 全科医学与补充医学 1 区 药学 1 区 植物科学
第一作者：
第一作者机构： [1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong,510515, China
共同第一作者：
通讯作者：
通讯机构： [1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong,510515, China [3]The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China [4]Guangdong Provincial Key Laboratory of Shock and Microcirculation, Southern Medical University, Guangzhou, 510515, China
推荐引用方式(GB/T 7714)：
Huang Sha,Wang Yuhua,Xie Shuwen,et al.Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice.[J].Phytomedicine : international journal of phytotherapy and phytopharmacology.2022,101:154117.doi:10.1016/j.phymed.2022.154117.
APA：
Huang Sha,Wang Yuhua,Xie Shuwen,Lai Yuqi,Mo Chan...&Lv Zhiping.(2022).Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice..Phytomedicine : international journal of phytotherapy and phytopharmacology,101,
MLA：
Huang Sha,et al."Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice.".Phytomedicine : international journal of phytotherapy and phytopharmacology 101.(2022):154117

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