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Oligo-peptide I-C-F-6 inhibits hepatic stellate cell activation and ameliorates CCl4-induced liver fibrosis by suppressing NF-κB signaling and Wnt/β-catenin signaling.

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机构： [1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China [2]Traditional Chinese Medicine Department of No. 458 Hospital of PLA, Guangdong 510602, China

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关键词： Oligo-peptide I-C-F-6 Hepatic fibrosis Hepatic stellate cells (HSCs) NF-kB signaling Wnt/b-catenin signaling

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Oligo-peptide I-C-F-6 is a Carapax trionycis extract component that has an effect on hepatic fibrosis, however, its mechanism of action is still unclear. This study investigated whether oligo-peptide I-C-F-6 could inhibit liver fibrosis by suppressing NF-κB and Wnt/β-catenin signaling, which are important in liver fibrosis. HSC-T6 cells were treated with oligo-peptide I-C-F-6, and rats were divided randomly into five groups: control (saline), CCl4, CCl4 plus oligo-peptide I-C-F-6 (0.12 and 0.24 mg/kg), and CCl4 plus colchicine (0.11 mg/kg). Here, we demonstrated that oligo-peptide I-C-F-6 ameliorated liver injury, inflammation, and hepatic fibrogenesis induced by CCl4. Oligo-peptide I-C-F-6 also inhibited the activation of hepatic stellate cells (HSCs) in vivo and in vitro, as evaluated by the expression of transforming growth factor-β1 (TGF-β1) and α-smooth muscle actin (α-SMA), which is a specific marker of HSC activation. Moreover, oligo-peptide I-C-F-6 significantly reduced the expression and distribution of β-catenin, P-AKT, phospho (P)-GSK-3β, nuclear factor κB (NF-κB) P65, phospho-P65, and IκB kinase α/β (IKK-α/β) levels; additionally, IκB-α level was elevated both in vivo and in vitro. Together, these results indicate that oligo-peptide I-C-F-6 has hepatoprotective and anti-fibrotic effects in animal models of liver fibrosis, the mechanism of which may be related to modulating NF-κB and Wnt/β-catenin signaling. Copyright © 2018 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

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出版当年[2017]版：

大类 | 3 区医学

小类 | 3 区药学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区药学

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第一作者机构： [1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China

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