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Evolving Roles of Natural Terpenoids From Traditional Chinese Medicine in the Treatment of Osteoporosis.

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机构： [1]Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China. [2]Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Women and Children's Medical Center, Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Guangzhou Medical University, Guangzhou, China. [3]Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States. [4]The Third Affiliated Hospital of Southern Medical University, Guangzhou, China. [5]The 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

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关键词： osteoporosis traditional Chinese medicine terpenoids osteoblast osteoclast

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Osteoporosis (OP) is a systemic metabolic skeletal disease which can lead to reduction in bone mass and increased risk of bone fracture due to the microstructural degradation. Traditional Chinese medicine (TCM) has been applied in the prevention and treatment of osteoporosis for a long time. Terpenoids, a class of natural products that are rich in TCM, have been widely studied for their therapeutic efficacy on bone resorption, osteogenesis, and concomitant inflammation. Terpenoids can be classified in four categories by structures, monoterpenoids, sesquiterpenoids, diterpenoids, and triterpenoids. In this review, we comprehensively summarize all the currently known TCM-derived terpenoids in the treatment of OP. In addition, we discuss the possible mechanistic-of-actions of all four category terpenoids in anti-OP and assess their therapeutic potential for OP treatment.Copyright © 2022 Zhuo, Li, Jiang, Ke, Liang, Zeng and Fang.

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出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区内分泌学与代谢

最新[2025]版：

大类 | 3 区医学

小类 | 3 区内分泌学与代谢

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第一作者机构： [1]Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China.

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