机构：[1]Beijing University of Chinese Medicine, Beijing, P.R. China[2]Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, P.R. China[3]Capital Medical University, Beijing, P.R. China[4]Beijing Anzhen Hospital, Capital Medical University, Beijing, P.R. China首都医科大学附属安贞医院[5]Shantou University Medical College, Shantou, Guangdong, P.R. China[6]Department of Rehabilitation Medicine, Guangdong Geriatric Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China广东省人民医院[7]Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China
Osteoporosis is an important health problem worldwide. Siwu decoction (SWD) and its modification have a good clinical effect on osteoporosis. However, the molecular mechanism of SWD on osteoporosis has not been thoroughly explained. A systematic pharmacological methodology was utilized to predict the active compounds and potential targets of SWD, collect the genes of osteoporosis and the known targets of SWD, and analyze the osteoporosis and SWD's network. Five networks were constructed and analyzed: (1) Osteoporosis genes' protein-protein interaction (PPI) network; (2) Compound-compound target network of SWD; (3) SWD-osteoporosis PPI network; (4) Compound-known target network of SWD; and (5) SWD known target- osteoporosis PPI network. Several osteoporosis and treatment-related targets (eg.,. HSP90AB1, FGFR1, HRAS, GRB2, and PGF), clusters, biological processes, and signaling pathways (e.g., PI3K-Akt signaling pathway, insulin signaling pathway, MAPK signaling pathway and FoxO signaling pathway) were found. The therapeutic effect of SWD on osteoporosis may be achieved by interfering with the biological processes and signaling pathways related to the development of osteoporosis.
基金：
the Dominant Disease Project of China Academy of Chinese Medical Sciences (CACMSO7Y004)
第一作者机构：[1]Beijing University of Chinese Medicine, Beijing, P.R. China[2]Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, P.R. China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Bao Tingting,Yang Kailin,Long Zhiyong,et al.Systematic Pharmacological Methodology to Explore the Pharmacological Mechanism of Siwu Decoction for Osteoporosis.[J].MEDICAL SCIENCE MONITOR.2019,25:8152-8171.doi:10.12659/MSM.917393.
APA：
Bao Tingting,Yang Kailin,Long Zhiyong,Zeng Liuting&Li Yuehua.(2019).Systematic Pharmacological Methodology to Explore the Pharmacological Mechanism of Siwu Decoction for Osteoporosis..MEDICAL SCIENCE MONITOR,25,
MLA：
Bao Tingting,et al."Systematic Pharmacological Methodology to Explore the Pharmacological Mechanism of Siwu Decoction for Osteoporosis.".MEDICAL SCIENCE MONITOR 25.(2019):8152-8171
