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FOXS1 Promotes Tumor Progression by Upregulating CXCL8 in Colorectal Cancer

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Qiu Junfeng[1,2,3] * ; Li Mingzhou[1,2] * ; Su Cailin[1,2,3] * ; Liang Yihao[4] ; Ou Ruizhang[1,2,3] ; Chen Xiaoning[1,2,3] ; Huang Chengmei[1,2,3] ; Zhang Yaxin[5] ; Ye Yaping[1,2,3] ; Liao Wenting[1,2,3,5] ; Zhang Chao[5] ;
机构： [1]Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China. [2]Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. [3]Department of Pathology, Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China. [4]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China. [5]State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China.
出处：
DOI： 10.3389/fonc.2022.894043
ISSN：

关键词： colorectal cancer FOXS1 CXCL8 angiogenesis invasion metastasis

摘要：
Forkhead box S1 (FOXS1) is a member of the forkhead box (FOX) transcriptional factor superfamily. The biological roles and underlying regulatory mechanism of FOXS1 in CRC remain unclear.Bioinformatics analysis, Western blotting, real-time PCR, and immunohistochemistry (IHC) were used to detect the expression FOXS1 in CRC. MTT assay, transwell assay, human umbilical vein endothelial cell tube formation assay, and chicken chorioallantoic membrane assay were performed to investigate the effects of FOXS1 on proliferation, invasion, and angiogenesis. Additionally, tumor formation assay and orthotopic implantation assay were used to investigate the effects of FOXS1 on tumor growth and metastasis in vivo. Furthermore, gene set enrichment analysis (GSEA) was used to analyze the correlation between FOXS1 and EMT or angiogenesis. The correlation between FOXS1 and CXCL8 expression was analyzed in clinical CRC samples using IHC.The results showed that FOXS1 expression was upregulated in CRC tissues compared with adjacent normal intestine tissues. A high FOXS1 expression is positively correlated with poor survival. FOXS1 promoted the malignant behavior of CRC cancer cells in vitro, including proliferation, invasion, and angiogenesis. In addition, FOXS1 promoted tumor growth and metastasis in nude mice. Mechanistically, FOXS1 upregulated the expression of C-X-C motif chemokine ligand 8 (CXCL8) at the transcriptional level. Knockdown of CXCL8 blocked FOXS1 induced the enhancement of the EMT and angiogenesis. GSEAs in public CRC datasets revealed strong correlations between FOXS1 expression and EMT marker and angiogenesis markers. IHC showed that FOXS1 expression was positively correlated with CXCL8 expression and CD31 expression in clinical CRC samples.The results suggest that FOXS1 promotes angiogenesis and metastasis by upregulating CXCL8 in CRC. Interference with the FOXS1/CXCL8 axis may serve as a potential therapeutic target for the treatment of metastatic CRC.Copyright © 2022 Qiu, Li, Su, Liang, Ou, Chen, Huang, Zhang, Ye, Liao and Zhang.

基金：
National Natural Science Foundation of China (No. 81872401, 81672886).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 医学
小类 | 3 区 肿瘤学
最新[2025]版：
大类 | 3 区 医学
小类 | 4 区 肿瘤学
JCR分区：
出版当年[2020]版：
Q2 ONCOLOGY
最新[2023]版：
Q2 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China. [2]Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. [3]Department of Pathology, Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China. [2]Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. [3]Department of Pathology, Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China. [5]State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China.
推荐引用方式(GB/T 7714)：
Qiu Junfeng,Li Mingzhou,Su Cailin,et al.FOXS1 Promotes Tumor Progression by Upregulating CXCL8 in Colorectal Cancer[J].FRONTIERS IN ONCOLOGY.2022,12:doi:10.3389/fonc.2022.894043.
APA：
Qiu Junfeng,Li Mingzhou,Su Cailin,Liang Yihao,Ou Ruizhang...&Zhang Chao.(2022).FOXS1 Promotes Tumor Progression by Upregulating CXCL8 in Colorectal Cancer.FRONTIERS IN ONCOLOGY,12,
MLA：
Qiu Junfeng,et al."FOXS1 Promotes Tumor Progression by Upregulating CXCL8 in Colorectal Cancer".FRONTIERS IN ONCOLOGY 12.(2022)

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