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Tumor perivascular cell-derived extracellular vesicles promote angiogenesis via the Gas6/Axl pathway.

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收录情况： ◇ SCIE

作者：
Huang Maohua[1,2] * ; Liu Mingqun[3] * ; Huang Dandan[4] * ; Ma Yanping[1] ; Ye Geni[1] ; Wen Qing[1] ; Li Yong[1] ; Deng Lijuan[5] ; Qi Qi[6] ; Liu Tongzheng[1] ; Liu Xiangning[3] ; Chen Minfeng[1] ; Ye Wencai[1] ; Zhang Dongmei[1] ;
机构： [1]Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China [2]Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, 510632, PR China [3]The First Affiliated Hospital, Jinan University, Guangzhou, 510632, PR China [4]The Sixth Affiliated Hospital, Sun Yet-sen University, Guangzhou, 510655, PR China [5]Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, PR China [6]MOE Key Laboratory of Tumor Molecular Biology, Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, 510632, PR China
出处：
DOI： 10.1016/j.canlet.2021.10.023
ISSN：

关键词： Perivascular cells Extracellular vesicles Colorectal cancer Angiogenesis

摘要：
Aberrant angiogenesis is a hallmark of cancer and is critically associated with tumor progression. Perivascular cells are essential components of blood vessels, and the role of tumor perivascular cell-derived extracellular vesicles (TPC-EVs) in angiogenesis remains elusive. In the present study, using genetic mouse models and pharmacological inhibitors, we found that ablation of perivascular cells inhibited angiogenesis in allografted colorectal cancer tumors. Further studies demonstrated that TPC-EVs promoted the proliferation, migration, invasion, viability, and tube formation of HUVECs. They also facilitated vessel spouting in rat aortic rings and induced neovascularization in chick chorioallantoic membranes (CAMs). Silencing of Gas6 or blockade of the Axl pathway suppressed TPC-EV-induced angiogenesis in vitro and ex vivo. Moreover, inhibition of the Gas6/Axl signaling pathway impaired TPC-EV-mediated angiogenesis in vivo. Our findings present a deeper insight into the biological functions of TPCs and TPC-EVs in tumor angiogenesis and demonstrate that TPC-EV-derived Gas6 could be an attractive and innovative regulator of tumor angiogenesis.Copyright © 2021 Elsevier B.V. All rights reserved.

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中科院(CAS)分区：
出版当年[2021]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学
最新[2025]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学
JCR分区：
出版当年[2020]版：
Q1 ONCOLOGY
最新[2023]版：
Q1 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China [2]Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, 510632, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Huang Maohua,Liu Mingqun,Huang Dandan,et al.Tumor perivascular cell-derived extracellular vesicles promote angiogenesis via the Gas6/Axl pathway.[J].CANCER LETTERS.2022,524:131-143.doi:10.1016/j.canlet.2021.10.023.
APA：
Huang Maohua,Liu Mingqun,Huang Dandan,Ma Yanping,Ye Geni...&Zhang Dongmei.(2022).Tumor perivascular cell-derived extracellular vesicles promote angiogenesis via the Gas6/Axl pathway..CANCER LETTERS,524,
MLA：
Huang Maohua,et al."Tumor perivascular cell-derived extracellular vesicles promote angiogenesis via the Gas6/Axl pathway.".CANCER LETTERS 524.(2022):131-143

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