Polyprenylated Benzophenones and Tocotrienol Derivatives from the Edible Fruits of Garcinia oblongifolia Champ. ex Benth. and Their Cytotoxicity Activity
机构：[1]Department of Radiology, The First Affiliated Hospital, Jinan University, Guangzhou 510632, P. R. China.[2]Precision Medicine and Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute (TBSI), Shenzhen Key Laboratory of Gene and Antibody Therapy, Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, Guangdong 518055, China.[3]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China.[4]Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, P. R. China.[5]The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, The First Affiliated Hospital, Jinan University, Guangzhou 510632, China.[6]Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, P. R. China.
The fruits of Garcinia oblongifolia Champ. ex Benth. were famous as an edible fruit in tropical regions of China. Because of its unique taste and great nutritional value, the ripe fresh fruits of G. oblongifolia could be eaten directly or used as raw materials for natural beverages and food supplements. In this work, six new polyprenylated benzophenones (1-6) and one new dimeric tocotrienol derivative (7), together with 18 known ones (8-25), were isolated from the fruits of G. oblongifolia. Compounds 1-4 were peculiar polycyclic polyprenylated acylphloroglucinols (PPAPs) featuring the rare carbon skeleton of a bicyclo[3.4.1]decane-1,3-diketone. Moreover, all isolates (1-25) were evaluated for their cytotoxicity activities against nasopharyngeal carcinoma (NPC) cell lines (CNE1 and CNE2). Among these isolates, compound 6 exhibited the strongest cytotoxicity activity on CNE1 and CNE2 cells with the IC50 values of 7.8 ± 0.2 and 9.1 ± 0.3 μM, respectively. Further mechanistic investigation demonstrated that 6 could induce mitophagy to promote Caspase-9/GSDME-mediated pyroptosis through triggering ROS in NPC cells.
基金：
This work was supported by grants from the National Natural
Science Foundation of China (nos. 82104015, 82173695,
82003609, and 81973190), the Guangdong Basic and Applied
Basic Research Foundation (nos. 2020A1515110415,
2 0 2 0 A 1 5 1 5 1 1 0 4 5 3 , 2 0 2 0 B 1 5 1 5 0 2 0 0 3 3 , a n d
2019A1515111161), China Postdoctoral Science Foundations
(nos. 2021M691261, 2021M701645, and 2019M663403),
Natural Science Foundation of Guangdong Province (no.
2018B030311020), Science and Technology Planning Project
of Guangdong Province (no. 2020B121201013), and the highperformance
public computing service platform of Jinan
University.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|1 区农林科学
小类|1 区农业综合2 区应用化学2 区食品科技
最新[2025]版：
大类|1 区农林科学
小类|1 区农业综合2 区应用化学2 区食品科技
第一作者：
第一作者机构：[1]Department of Radiology, The First Affiliated Hospital, Jinan University, Guangzhou 510632, P. R. China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Radiology, The First Affiliated Hospital, Jinan University, Guangzhou 510632, P. R. China.[3]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China.[5]The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, The First Affiliated Hospital, Jinan University, Guangzhou 510632, China.[6]Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, P. R. China.[*1]Department of Radiology, The First Affiliated Hospital, Jinan University, Guangzhou 510632, P. R. China[*2]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China[*3]The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, The First Affiliated Hospital, Jinan University, Guangzhou 510632, China[*4]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy and Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, P. R. China[*5]The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, The First Affiliated Hospital, Jinan University, Guangzhou 510632, China
推荐引用方式(GB/T 7714)：
Wu Zhongnan,Dai Xiaoyong,Wang Wenzhi,et al.Polyprenylated Benzophenones and Tocotrienol Derivatives from the Edible Fruits of Garcinia oblongifolia Champ. ex Benth. and Their Cytotoxicity Activity[J].Journal of agricultural and food chemistry.2022,doi:10.1021/acs.jafc.2c04216.
APA：
Wu Zhongnan,Dai Xiaoyong,Wang Wenzhi,Zhang Xianfang,Chen Jiawei...&Zhang Yubo.(2022).Polyprenylated Benzophenones and Tocotrienol Derivatives from the Edible Fruits of Garcinia oblongifolia Champ. ex Benth. and Their Cytotoxicity Activity.Journal of agricultural and food chemistry,,
MLA：
Wu Zhongnan,et al."Polyprenylated Benzophenones and Tocotrienol Derivatives from the Edible Fruits of Garcinia oblongifolia Champ. ex Benth. and Their Cytotoxicity Activity".Journal of agricultural and food chemistry .(2022)
农林科学