机构：[1]Key Laboratory of Quality Evaluation of Chinese Medicine of the Guangdong Provincial Medical Products Administration, The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510006, China广东省中医院[2]State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei 230036, China[3]Department Pharmaceutical Biosciences, Uppsala University, Uppsala 75123, Sweden
Evidence suggests that the immunomodulatory property of polyphenols may also contribute to the reduction of cardiovascular risk. In the present study, we investigated the polyphenol extraction (PE) from Syzygium brachythyrsum, a functional food resource in south China, regarding the protective effect on inhibiting foam cell formation and the underlying molecular mechanism based on an ox-LDL-induced RAW264.7 macrophage model. The results of Oil Red O staining, Dil-ox-LDL fluorescent staining, and cholesterol efflux experiments showed that PE, and its two phenolics brachythol B (BB) and ethyl gallate (EG), significantly inhibited the foam cell formation, which may be associated with reducing the expression of SR-A1 and CD36 while increasing expression of SR-B1, ABCG1, and PPAR gamma. In addition, BB and EG also reduce the inflammatory response by down-regulating the expression of NF-kappa B and MAPK signal pathway proteins, thereby inhibiting the expression of inflammatory factors. Altogether, PE and its two components BB and EG attenuated foam cell formation and macrophage inflammation response.
基金：
This work was supported by the Special Foundation of Guangzhou Key Laboratory
(No. 202002010004), the Foundation of Administration of Traditional Chinese Medicine of Guangdong
Province (No. 20221311) and the National Natural Science Foundation of China (81803482).
第一作者机构：[1]Key Laboratory of Quality Evaluation of Chinese Medicine of the Guangdong Provincial Medical Products Administration, The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
通讯作者：
通讯机构：[1]Key Laboratory of Quality Evaluation of Chinese Medicine of the Guangdong Provincial Medical Products Administration, The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510006, China[3]Department Pharmaceutical Biosciences, Uppsala University, Uppsala 75123, Sweden
推荐引用方式(GB/T 7714)：
Chen Xue-Lian,Liang Pu-Lin,Gong Ming-Jiong,et al.Polyphenolics from Syzygium brachythyrsum Inhibits Oxidized Low-Density Lipoprotein-Induced Macrophage-Derived Foam Cell Formation and Inflammation[J].FOODS.2022,11(21):doi:10.3390/foods11213543.
APA：
Chen, Xue-Lian,Liang, Pu-Lin,Gong, Ming-Jiong,Xu, Ya,Zhang, Liang...&Xu, Wen.(2022).Polyphenolics from Syzygium brachythyrsum Inhibits Oxidized Low-Density Lipoprotein-Induced Macrophage-Derived Foam Cell Formation and Inflammation.FOODS,11,(21)
MLA：
Chen, Xue-Lian,et al."Polyphenolics from Syzygium brachythyrsum Inhibits Oxidized Low-Density Lipoprotein-Induced Macrophage-Derived Foam Cell Formation and Inflammation".FOODS 11..21(2022)
