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Gypenoside LVI attenuates foam cell formation by promoting cholesterol export and inhibiting inflammation response

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机构： [a]College of Food and Bioengineering, South China University of Technology, Guangzhou 510640, China [b]The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510120, China [c]Sci-tech Industrial Park, Guangzhou University of Chinese Medicine, Guangzhou 510120, China

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关键词： Atherosclerosis Foam cell formation Gypenoside LVI Gynostemma pentaphyllum Macrophages

摘要：

Gynostemma pentaphyllum was widely consumed in China because of its various pharmacological activities. Numerous studies have confirmed the beneficial effects of G. pentaphyllum. However, the ultimate compounds responsible for its inhibitory effects on foam cell formation were still unknown. Gypenoside LVI (GPLVI), a dammarane-type gynosaponin was isolated and identified from G. pentaphyllum. Treatment of GPLVI successfully attenuated foam cell formation, as evidenced by Oil Red O staining, TG and cholesterol contents, and Dil-ox-LDL uptake analyses. GPLVI displayed significant inhibitory effects on secretion of IL-6 and IL-1 beta. In contrast, production of TNF-alpha was not markedly reduced. GPLVI also markedly induced ABCG1, SRB1 and LXR alpha expression. Additionally, GPLVI significantly blocked phosphorylation of ERK and JNK. Taken together, our results suggested that GPLVI might be responsible for the inhibitory effect of G. pentaphyllum on ox-LDL-induced foam cell formation mainly by promoting cholesterol efflux and inhibiting inflammatory response.

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出版当年[2017]版：

大类 | 2 区

工程技术

小类 | 1 区食品科技

最新[2025]版：

大类 | 2 区农林科学

小类 | 3 区食品科技 4 区营养学

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出版当年[2016]版：

Q1 FOOD SCIENCE & TECHNOLOGY

最新[2023]版：

Q2 FOOD SCIENCE & TECHNOLOGY Q2 NUTRITION & DIETETICS

影响因子： 3.8 最新[2023版] 4.6 最新五年平均 3.144 出版当年[2016版] 3.46 出版当年五年平均 3.973 出版前一年[2015版] 3.47 出版后一年[2017版]

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第一作者机构： [a]College of Food and Bioengineering, South China University of Technology, Guangzhou 510640, China

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