机构：[1]Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China深圳市中医院深圳医学信息中心[2]Institute of Microscale Optoelectronics, Collaborative Innovation Centre for Optoelectronic Science & Technology, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology, Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), Shenzhen University, Shenzhen 518060, China[3]College of Health Science and Environmental Engineering, School of Shenzhen Technology University, Shenzhen 518118, China深圳市康宁医院深圳医学信息中心[4]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China[5]Institute of Pediatrics, Shenzhen Children’s Hospital, Shenzhen 518038, China[6]Shenzhen International Institute for Biomedical Research, Shenzhen 518116, China
Near-infrared (NIR)-light-triggered photothermal therapy (PTT) is a promising treatment for breast cancer. However, its therapeutic efficiency is often compromised due to the heat -induced up-regulation of heat shock proteins, which confer photothermal resistance. To solve this urgent problem, PEGylated two-dimensional boron nanosheets (B-PEG)-which allow both multimodal imaging and photothermal conversion-were loaded with gambogic acid (GA), which can inhibit heat shock protein 90 (Hsp90). Experimental findings indicated that this combination of B-PEG and GA could serve as an integrated drug delivery system for cancer diagnosis and treatment. It could be used to administer mild PTT as well as chemotherapy for breast cancer, provide improved anti-tumor effects, and reduce the toxicity of PTT, all while inhibiting breast cancer growth. This drug delivery system could offer a novel tool for administering chemotherapy combined with PTT while avoiding the adverse effects of traditional PTT. (c) 2022 Shenyang Pharmaceutical University. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
基金：
Guangdong Basic and Applied Basic Research Foundation [2019B1515120043, 2022A1515012154]; National Natural Science Foundation of China [82104354, 81960334]; Shenzhen Fundamental Research Program [JCYJ20180507181817604]; Science and Technology Development Fund , Macau SAR [0016/2021/A]; Instrumental Analysis Center of Shenzhen University
医学