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Therapeutic perspectives of heat shock proteins and their protein -protein interactions in myocardial infarction

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收录情况： ◇ SCIE

作者：
Junxuan Wu [a,b] * ; Sixuan Chen [a] * ; Yuntao Liu [c] ; Zhongqiu Liu [a,b] ; Dawei Wang [b] ; Yuanyuan Cheng [a] ;
机构： [a]Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China [b]Shunde Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan, Guangdong, 528333, China [c]Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China
出处：
DOI： 10.1016/j.phrs.2020.105162
ISSN：

关键词： Cardioprotective role Heat shock proteins Myocardial infarction Protein-protein interactions Therapeutic strategies

摘要：
Myocardial infarction (MI) is one of major causes of human death around the world. Heat shock proteins (HSPs) are a large family of conserved proteins, which can promote correct protein folding, maintain protein stability, and regulate cell metabolism, cellular homeostasis and other biological processes as molecular chaperones. Notable, HSPs are involved in MI-related pathophysiology, such as apoptosis, inflammatory response and oxidative stress. Here, we review recent studies and systematically summarize the role of HSPs in MI and myocardial ischemia/reperfusion injury (MIRI) and discuss the role of direct and indirect protein-protein interactions (PPI) of HSP complexes in the pathophysiology and therapeutic strategies of myocardial infarction. A comprehensive understanding of the cardioprotective role of PPIs of HSP complexes in myocardial infarction can provide new insights for MI or MIRI therapy. © 2020 Elsevier Ltd

语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 2 区 医学
小类 | 1 区 药学
最新[2025]版：
大类 | 2 区 医学
小类 | 1 区 药学
JCR分区：
出版当年[2018]版：
Q1 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [a]Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China [b]Shunde Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan, Guangdong, 528333, China
共同第一作者：
通讯作者：
通讯机构： [a]Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China [b]Shunde Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan, Guangdong, 528333, China
推荐引用方式(GB/T 7714)：
Junxuan Wu,Sixuan Chen,Yuntao Liu,et al.Therapeutic perspectives of heat shock proteins and their protein -protein interactions in myocardial infarction[J].PHARMACOLOGICAL RESEARCH.2020,160:doi:10.1016/j.phrs.2020.105162.
APA：
Junxuan Wu,Sixuan Chen,Yuntao Liu,Zhongqiu Liu,Dawei Wang&Yuanyuan Cheng.(2020).Therapeutic perspectives of heat shock proteins and their protein -protein interactions in myocardial infarction.PHARMACOLOGICAL RESEARCH,160,
MLA：
Junxuan Wu,et al."Therapeutic perspectives of heat shock proteins and their protein -protein interactions in myocardial infarction".PHARMACOLOGICAL RESEARCH 160.(2020)

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