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Non-coding RNAs as potential biomarkers in osteosarcoma

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机构: [1]Henan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou, Henan, China. [2]Luoyang Postgraduate Training Department, Henan University of Chinese Medicine, Zhengzhou, Henan, China. [3]Department of Spinal Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China. [4]School of Clinical Medicine, Guilin Medical University, Guilin, Guangxi, China. [5]The First College for Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
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关键词: osteosarcoma non-coding RNAs biomarker diagnosis treatment prognosis

摘要:
Osteosarcoma (OS) is a primary solid malignant tumor that occurs most frequently in the metaphysis of long bones. More likely to happen to children and adolescents. OS has high mortality and disability rate. However, the etiology and pathogenesis of OS have not been fully understood till now. Due to the lack of effective biomarkers, OS cannot be precisely detected in the early stage. With the application of next-generation and high-throughput sequencing, more and more abnormally expressed non-coding RNAs(ncRNAs) have been identified in OS. Growing evidences have suggested the ncRNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), have played an important role in the tumorigenesis and progression of OS. Thus, they can be served as novel biomarkers for diagnosis, treatment and prognosis. This review summarized the application of ncRNA as biomarkers in OS in detail, and discussed the limitation and future improvement of the potential biomarkers.Copyright © 2022 Fan, Zhong, Lin and Li.

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出版当年[2021]版:
大类 | 3 区 生物学
小类 | 3 区 遗传学
最新[2025]版:
大类 | 3 区 生物学
小类 | 3 区 遗传学
第一作者:
第一作者机构: [1]Henan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou, Henan, China. [2]Luoyang Postgraduate Training Department, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
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通讯机构: [1]Henan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou, Henan, China. [2]Luoyang Postgraduate Training Department, Henan University of Chinese Medicine, Zhengzhou, Henan, China. [5]The First College for Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
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