机构：[1]Department of Pharmacology of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China广东省中医院[2]School of Bioscience and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, China[3]Guangzhou Virotech Pharmaceutical Co., Ltd, Guangzhou, China[4]Department of Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China大德路总院珠海院区病理科病理科大德路总院病理科广东省中医院深圳市中医院深圳医学信息中心
Advances in transcriptome sequencing have revealed that the genome fraction largely encodes for thousands of non-coding RNAs. Long non-coding RNAs (lncRNAs), which are a class of non-protein-coding RNAs longer than approximately 200 nucleotides in length, are emerging as key epigenetic regulators of gene expression recently. Intensive studies have characterized their crucial roles in cutaneous biology and diseases. In this review, we address the promotive or suppressive effects of lncRNAs on cutaneous physiological processes. Then, we focus on the pathogenic role of dysfunctional lncRNAs in a variety of proliferative skin diseases. These evidences suggest that lncRNAs have indispensable roles in the processes of skin biology. Additionally, lncRNAs might be promising biomarkers and therapeutic targets for cutaneous disorders.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81602748]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030310291, 2017A030313639]; The Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine [YN2015QN03, YN2016YX03, YN2018QJ03]; Medical Scientific Research Foundation of Guangdong Province [A2017277]
第一作者机构：[1]Department of Pharmacology of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pharmacology of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China[4]Department of Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China[*1]Department of Pharmacology of Traditional Chinese Medicine and Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou 510120, China.
推荐引用方式(GB/T 7714)：
Tang Lipeng,Liang Yongxin,Xie Hesong,et al.Long non-coding RNAs in cutaneous biology and proliferative skin diseases: Advances and perspectives[J].CELL PROLIFERATION.2020,53(1):doi:10.1111/cpr.12698.
APA：
Tang, Lipeng,Liang, Yongxin,Xie, Hesong,Yang, Xiaozhi&Zheng, Guangjuan.(2020).Long non-coding RNAs in cutaneous biology and proliferative skin diseases: Advances and perspectives.CELL PROLIFERATION,53,(1)
MLA：
Tang, Lipeng,et al."Long non-coding RNAs in cutaneous biology and proliferative skin diseases: Advances and perspectives".CELL PROLIFERATION 53..1(2020)
生物学