详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney Disease

12| 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Nephrology and State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China, [2]Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China, [3]Guangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney Diseases, Guangdong Academy of Medical Sciences, Guangdong Provincial People’s Hospital, Guangzhou, China, [4]Guangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney Diseases, The Chinese University of Hong Kong, Hong Kong, China

出处：

DOI：

ISSN：

关键词： biomarker diabetic kidney disease fibrosis inflammation long non-coding RNAs micro RNAs TGF-β therapeutic target

摘要：

Diabetic kidney disease (DKD) is the most common diabetic complication and is a leading cause of end-stage kidney disease. Increasing evidence shows that DKD is regulated not only by many classical signaling pathways but also by epigenetic mechanisms involving chromatin histone modifications, DNA methylation, and non-coding RNA (ncRNAs). In this review, we focus on our current understanding of the role and mechanisms of ncRNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the pathogenesis of DKD. Of them, the regulatory role of TGF-β/Smad3-dependent miRNAs and lncRNAs in DKD is highlighted. Importantly, miRNAs and lncRNAs as biomarkers and therapeutic targets for DKD are also described, and the perspective of ncRNAs as a novel therapeutic approach for combating diabetic nephropathy is also discussed. © Copyright © 2021 Gu, Lu, Huang, Zhang, Mao, Yu, Liu and Lan.

基金：

语种：

高被引：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2020]版：

大类 | 2 区医学

小类 | 2 区药学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区药学

JCR分区：

出版当年[2019]版：

Q1 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY

影响因子： 4.4 最新[2023版] 5 最新五年平均 4.225 出版当年[2019版] 4.604 出版当年五年平均 3.845 出版前一年[2018版] 5.811 出版后一年[2020版]

第一作者：

第一作者机构： [1]Department of Nephrology and State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China, [2]Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China,

通讯作者：

通讯机构： [2]Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China, [3]Guangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney Diseases, Guangdong Academy of Medical Sciences, Guangdong Provincial People’s Hospital, Guangzhou, China, [4]Guangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney Diseases, The Chinese University of Hong Kong, Hong Kong, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney Disease. [2]Kidney diseases and long non-coding RNAs in the limelight [3]Exploring Long Non-Coding RNAs Associated with IP3/DAG Signaling Pathway as Potential Biomarkers Involved in Mast Cell Degranulation in Chronic Spontaneous Urticaria with 2-Year Follow-Up. [4]The role of non‑coding RNAs in the regulation, diagnosis, prognosis and treatment of osteosarcoma (Review). [5]Long non-coding RNAs in cutaneous biology and proliferative skin diseases: Advances and perspectives [6]Functions and Roles of Long-Non-Coding RNAs in Human Nasopharyngeal Carcinoma [7]The differential profiles of long non-coding RNAs between rheumatoid arthritis and gouty arthritis. [8]The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis [9]Introduction of long non-coding RNAs to regulate autophagy-associated therapy resistance in cancer [10]The Differential Profiles of Long Non-coding RNAs Between Rheumatoid Arthritis and Gouty Arthritis

Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney Disease $(function () { $("[data-toggle='tooltip']").tooltip(); });

文献详情

相关文献

Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney Disease