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A mechanistic review of chinese medicine polyphenols on bone formation and resorption

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机构: [1]College of Traditional Chinese Medicine, Jinan University, Guangzhou, China. [2]Cancer Research Institute, Jinan University, Guangzhou, China. [3]Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization, Jinan University, Guangzhou, China. [4]College of Pharmacy, Jinan University, Guangzhou, China. [5]First Affiliated Hospital of Jinan University, Guangzhou, China. [6]Foshan Hospital of Traditional Chinese Medicine, Foshan, China.
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关键词: Chinese herbal medicine polyphenols bone resorption bone formation osteoblast osteoclast

摘要:
Bone reconstruction includes a steady state system of bone formation and bone absorption. This tight coupling requires subtle coordination between osteoblasts and osteoclasts. If this balance is broken, it will lead to bone mass loss, bone density reduction, and bone metabolic diseases, such as osteoporosis. Polyphenols in Chinese herbal medicines are active ingredients in plant extracts with high safety and few side effects, and they can play a role in affecting bone formation and bone resorption. Some of these have estrogen-like effects and can better target bone health in postmenopausal women. The purpose of this review is to provide comprehensive information on the mechanisms underlying the relationship between traditional Chinese medicine polyphenols and bone formation or bone resorption.Copyright © 2022 Li, Li, Li, Luo, Ye, Wang, Yang, Zhu, Han, Zhang, Tian and Wang.

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出版当年[2021]版:
大类 | 2 区 医学
小类 | 2 区 药学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 药学
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第一作者机构: [1]College of Traditional Chinese Medicine, Jinan University, Guangzhou, China.
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通讯作者:
通讯机构: [2]Cancer Research Institute, Jinan University, Guangzhou, China. [3]Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization, Jinan University, Guangzhou, China. [4]College of Pharmacy, Jinan University, Guangzhou, China. [5]First Affiliated Hospital of Jinan University, Guangzhou, China.
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