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Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：领军期刊

作者：
Fan Xiaoqing[1] * ; Mai Chutian[1] * ; Zuo Ling[2] * ; Huang Jumin[1] ; Xie Chun[3] ; Jiang Zebo[4] ; Li Runze[5] ; Yao Xiaojun[1] ; Fan Xingxing[1] ; Wu Qibiao[1] ; Yan Peiyu[1] ; Liu Liang[5] ; Chen Jianxin[2] ; Xie Ying[5] ; Leung Elaine Lai-Han[3] ;
机构： [1]Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau 999078, China. [2]Beijing University of Chinese Medicine, Beijing 100029, China. [3]Cancer Center, Faculty of Health Science.MOE Frontiers Science Center for Precision Oncology, University of Macau, Macau 999078, China. [4]Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China. [5]State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510120, China.
出处：
DOI： 10.1016/j.apsb.2022.10.016
ISSN：

关键词： BaWeiBaiDuSan Sepsis-induced liver injury Network pharmacology 16S PacBio SMRT sequencing Lactobacillus johnsonii Macrophages Interleukin-10

摘要：
Sepsis-induced liver injury (SILI) is an important cause of septicemia deaths. BaWeiBaiDuSan (BWBDS) was extracted from a formula of Panax ginseng C. A. Meyer, Lilium brownie F. E. Brown ex Miellez var. viridulum Baker, Polygonatum sibiricum Delar. ex Redoute, Lonicera japonica Thunb., Hippophae rhamnoides Linn., Amygdalus Communis Vas, Platycodon grandiflorus (Jacq.) A. DC., and Cortex Phelloderdri. Herein, we investigated whether the BWBDS treatment could reverse SILI by the mechanism of modulating gut microbiota. BWBDS protected mice against SILI, which was associated with promoting macrophage anti-inflammatory activity and enhancing intestinal integrity. BWBDS selectively promoted the growth of Lactobacillus johnsonii (L. johnsonii) in cecal ligation and puncture treated mice. Fecal microbiota transplantation treatment indicated that gut bacteria correlated with sepsis and was required for BWBDS anti-sepsis effects. Notably, L. johnsonii significantly reduced SILI by promoting macrophage anti-inflammatory activity, increasing interleukin-10+ M2 macrophage production and enhancing intestinal integrity. Furthermore, heat inactivation L. johnsonii (HI-L. johnsonii) treatment promoted macrophage anti-inflammatory activity and alleviated SILI. Our findings revealed BWBDS and gut microbiota L. johnsonii as novel prebiotic and probiotic that may be used to treat SILI. The potential underlying mechanism was at least in part, via L. johnsonii-dependent immune regulation and interleukin-10+ M2 macrophage production.© 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

基金：
Department of Pathology, University Hospital, Macau University of Science and Technology for the preparation of paraffin sections. We also thank Dr. Zhihong Li from Dong Zhi Mun Hospital Affiliated to Beijing University of Chinese Medicine for his kindly providing BWBDS. This work was funded by regular grants and joint grant (File No. 0096/2018/ A3, 0111/2020/A3 and 0056/2020/AMJ), Dr. Neher’s Biophysics Laboratory for Innovative Drug Discovery (File No. 001/2020/ ALC), supported by the Macau Science and Technology Development Fund, supported by 2020 Young Qihuang Scholar funded by the National Administration of Traditional Chinese Medicine. This work was supported by National Natural Science Foundation of China (82025036). This work was also financially supported by the Start-up Research Grant of University of Macau (SRG2022- 00020-FHS, China) and the Faculty of Health Science, University of Macau (Macau, China).
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外文
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出版当年[2022]版：
大类 | 1 区 化学
小类 | 1 区 药学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 药学
JCR分区：
出版当年[2021]版：
Q1 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau 999078, China.
共同第一作者：
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推荐引用方式(GB/T 7714)：
Fan Xiaoqing,Mai Chutian,Zuo Ling,et al.Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice[J].ACTA PHARMACEUTICA SINICA B.2023,13(3):1164-1179.doi:10.1016/j.apsb.2022.10.016.
APA：
Fan Xiaoqing,Mai Chutian,Zuo Ling,Huang Jumin,Xie Chun...&Leung Elaine Lai-Han.(2023).Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice.ACTA PHARMACEUTICA SINICA B,13,(3)
MLA：
Fan Xiaoqing,et al."Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice".ACTA PHARMACEUTICA SINICA B 13..3(2023):1164-1179

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