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Single-nucleus RNA sequencing unveils critical regulators in various hippocampal neurons for anti-N-methyl-D-aspartate receptor encephalitis

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收录情况： ◇ SCIE

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机构： [1]Department of Nephrology, Shenzhen Key Laboratory of Kidney Diseases, Shenzhen People's Hospital, the First Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, China. [2]Department of Neurology, Guangzhou First People's Hospital, School of Medicine, Southern China University of Technology, Guangzhou, China. [3]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China. [4]Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China. [5]Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, China. [6]Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China.

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关键词： anti-N-methyl-D-aspartate receptor encephalitis hippocampus neuronal types single-nucleus RNA sequencing

摘要：

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a neuropsychiatric disease with variable clinical manifestations caused by NMDAR autoantibody. The underlying molecular underpinnings of this disease are rarely characterized on a genomic scale. Anti-NMDAR encephalitis mainly affects the hippocampus, however, its effect on gene expression in hippocampal neurons is unclear at present. Here, we construct the active and passive immunization mouse models of anti-NMDAR encephalitis, and use single-nucleus RNA sequencing to investigate the diverse expression profile of neuronal populations isolated from different hippocampal regions. Dramatic changes in cell proportions and differentially expressed genes were observed in excitatory neurons of the dentate gyrus (DG) subregion. In addition, we found that ATP metabolism and biosynthetic regulators related genes in excitatory neurons of DG subregion were significantly affected. Kcnq1ot1 in inhibitory neurons and Meg3 in interneurons also changed. Notably, the latter two molecules exhibited opposite changes in different models. Therefore, the above genes were used as potential targets for further research on the pathological process of anti-NMDAR encephalitis. These data involve various hippocampal neurons, which delineate a framework for understanding the hippocampal neuronal circuit and the potential molecular mechanisms of anti-NMDAR encephalitis.© 2023 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.

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出版当年[2022]版：

大类 | 2 区医学

小类 | 1 区病理学 2 区神经科学 2 区临床神经病学

最新[2025]版：

大类 | 2 区医学

小类 | 1 区病理学 2 区临床神经病学 2 区神经科学

JCR分区：

出版当年[2021]版：

Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES Q1 PATHOLOGY

最新[2023]版：

Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES Q1 PATHOLOGY

影响因子： 5.8 最新[2023版] 6 最新五年平均 7.611 出版当年[2021版] 7.463 出版当年五年平均 6.508 出版前一年[2020版] 6.4 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Nephrology, Shenzhen Key Laboratory of Kidney Diseases, Shenzhen People's Hospital, the First Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, China.

共同第一作者：

通讯作者：

通讯机构： [1]Department of Nephrology, Shenzhen Key Laboratory of Kidney Diseases, Shenzhen People's Hospital, the First Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, China. [2]Department of Neurology, Guangzhou First People's Hospital, School of Medicine, Southern China University of Technology, Guangzhou, China. [*1]Department of Nephrology, and Shenzhen Key Laboratory of Kidney Diseases, Shenzhen People’s Hospital, the First Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China. [*2]Department of Neurology, Guangzhou First People’s Hospital, School of Medicine, Southern China University of Technology, Guangzhou 510180, China.

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Single-nucleus RNA sequencing unveils critical regulators in various hippocampal neurons for anti-N-methyl-D-aspartate receptor encephalitis

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