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Network Pharmacology Study to reveal the mechanism of Zuogui Pill for treating osteoporosis

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机构: [1]Nanjing University of Chinese Medicine, Nanjing 210000, Jiangsu, China. [2]Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, Guangdong, China. [3]The fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, Guangdong, China.
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关键词: Bioassays natural products network pharmacology molecular docking osteoporosis Zuogui pill

摘要:
To our knowledge, there is still a lack of scientific reports on the pharmacological mechanism of the Zuogui Pill (ZGP) for treating osteoporosis (OP). This study aimed to explore it via network pharmacology and molecular docking.We identified active compounds and associated targets in ZGP via two drug databases. Disease targets of OP were obtained utilizing five disease databases. Networks were established and analyzed through the Cytoscape software and STRING databases. Enrichment analyses were performed using the DAVID online tools. Molecular docking was performed using Maestro, PyMOL, and Discovery Studio software.89 drug active compounds, 365 drug targets, 2514 disease targets, and 163 drug-disease common targets were obtained. Quercetin, kaempferol, phenylalanine, isorhamnetin, betavulgarin, and glycitein may be the crucial compounds of ZGP in treating OP. AKT1, MAPK14, RELA, TNF, and JUN may be the most important therapeutic targets. Osteoclast differentiation, TNF, MAPK, and thyroid hormone signaling pathways may be the critical therapeutic signaling pathways. The potential therapeutic mechanism mainly relates to osteoblastic or osteoclastic differentiation, oxidative stress, and osteoclastic apoptosis.This study has revealed the anti-OP mechanism of ZGP, which offers objective evidence for relevant clinical application and further basic research.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

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出版当年[2023]版:
大类 | 4 区 医学
小类 | 4 区 药物化学 4 区 计算机:跨学科应用
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 药物化学 4 区 计算机:跨学科应用
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出版当年[2022]版:
Q4 CHEMISTRY, MEDICINAL Q4 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS
最新[2023]版:
Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS Q4 CHEMISTRY, MEDICINAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

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第一作者机构: [1]Nanjing University of Chinese Medicine, Nanjing 210000, Jiangsu, China. [2]Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, Guangdong, China.
通讯作者:
通讯机构: [2]Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, Guangdong, China. [*1]Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong, China
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