高级检索
当前位置: 首页 > 详情页

Coating of chitosan on poly D,L-lactic-co-glycolic acid thymoquinone nanoparticles enhances the anti-tumor activity in triple-negative breast cancer

文献详情

资源类型:
WOS体系:
Pubmed体系:

收录情况: ◇ SCIE

机构: [1]School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, China. [2]School of Food Science and Engineering, South China University of Technology, Guangzhou, China. [3]Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan, China. [4]Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), Guangzhou, China. [5]China-Singapore International Joint Research Institute, Guangzhou, China. [6]Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (ASTAR), Singapore, Singapore. [7]Department of Food Science and Technology, Khwaja Fareed University of Engineering and Information Technology, Rahimyar Khan, Punjab, Pakistan. [8]Enzymology and nanotechnology laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India. [9]Institute for Nano Scale and Technology, College of Science and Engineering, Flinders University, Bedford Park, SA, Australia. [10]College of Engineering, Information, Technology & Environment, Charles Darwin University, Darwin, NT, Australia. [11]The Department of Anaesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
出处:
ISSN:

关键词: thymoquinone triple negative breast cancer polymeric nanoparticles polylactic acid chitosan hybrid nanoparticles

摘要:
Breast cancer is the second most common cancer around the world. Triple-negative breast cancer (TNBC) is characterized by the absence of three receptors: progesterone, estrogen, and human epidermal growth factor-2 receptor (HER2). Various synthetic chemotherapies have gained attention but they caused unwanted side effects. Therefore, some secondary therapies are now becoming famous against this disease. For instance, natural compounds have been extensively researched against many diseases. However, enzymatic degradation and low solubility remain a major concern. To combat these issues, various nanoparticles have been synthesized and optimized from time to time, which increases its solubility and hence therapeutic potential of a particular drug increases. In this study, we have synthesized Poly D,L-lactic-co-glycolic acid (PLGA) loaded thymoquinone (TQ) nanoparticle (PLGA-TQ-NPs) and then coated them by chitosan (CS) (PLGA-CS-TQ-NPs), which was characterized by different methods. Size of non-coated NPs was 105 nm with PDI value of 0.3 and the size of coated NPs was 125 nm with PDI value of 0.4. Encapsulation efficiency (EE%) and Drug loading (DL%) was found to be 70.5 ± 2.33 and 3.38 for non-coated and 82.3 ± 3.11 and 2.66 for coated NPs respectively. We have also analysed their cell viability against MDA-MB-231 and SUM-149 TNBC cell lines. The resultant, nanoformulations exhibit anti-cancerous activity in a dose and time-dependent manner for MDA-MB-231 and SUM-149 cell lines with an IC50 value of (10.31 ± 1.15, 15.60 ± 1.25, 28.01 ± 1.24) and (23.54 ± 1.24, 22.37 ± 1.25, 35 ± 1.27) for TQ free, PLGA-TQ-NPs and PLGA-CS-TQ-NPs respectively. For the first time, we have developed a nanoformulations of PLGA loaded TQ coated with CS NPs (PLGA-CS-TQ-NPs) against TNBC which led to their enhanced anti-cancerous effects.Copyright © 2023 Gao, Kumari, Zeng, Chan, Farooq, Alee, Khan, Rahaman, He, Xin and Mehmood.

基金:
语种:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2022]版:
大类 | 3 区 化学
小类 | 3 区 化学:综合
最新[2025]版:
大类 | 3 区 化学
小类 | 4 区 化学:综合
JCR分区:
出版当年[2021]版:
Q2 CHEMISTRY, MULTIDISCIPLINARY
最新[2023]版:
Q2 CHEMISTRY, MULTIDISCIPLINARY

影响因子: 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者:
第一作者机构: [1]School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, China. [2]School of Food Science and Engineering, South China University of Technology, Guangzhou, China.
通讯作者:
通讯机构: [1]School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, China. [2]School of Food Science and Engineering, South China University of Technology, Guangzhou, China. [3]Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan, China. [4]Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), Guangzhou, China. [5]China-Singapore International Joint Research Institute, Guangzhou, China. [9]Institute for Nano Scale and Technology, College of Science and Engineering, Flinders University, Bedford Park, SA, Australia. [10]College of Engineering, Information, Technology & Environment, Charles Darwin University, Darwin, NT, Australia.
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:2018 今日访问量:0 总访问量:645 更新日期:2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持:重庆聚合科技有限公司 地址:广州市越秀区大德路111号