个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Clinical characteristics and prognosis of non-APAP drug-induced acute liver failure: a large multicenter cohort study

| 认领 | 导出 | |

文献详情

资源类型：
Pubmed体系：
作者：
Lin Han[1] * ; Ang Huang[1] ; Jinjun Chen[2] ; Guangju Teng[1] ; Ying Sun[1] ; Binxia Chang[1] ; Hong‑Li Liu[3,4] ; Manman Xu[5,6] ; Xiaoqin Lan[2] ; Qingsheng Liang[1] ; Jun Zhao[1] ; Hui Tian[1] ; Songhai Chen[1] ; Yun Zhu[1] ; Huan Xie[1] ; Tong Dang[7] ; Jing Wang[7] ; Ning Li[1] ; Xiaoxia Wang[8] ; Yu Chen[5,6] ; Yong‑Feng Yang[3,4,9] ; Dong Ji[1,10] ; Zhengsheng Zou[1,10] ;
机构： [1]Senior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing 100039, China [2]State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China [3]Southeast University School of Medicine, No. 87 Dingjiaqiao Road, Gulou District, Nanjing 210003, China [4]The Second Hospital of Nanjing, Teaching Hospital of Southeast University, No. 1‑1 Zhongfu Road, Gulou District, Nanjing 210003, China [5]Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmenwai Street, Fengtai District, Beijing 100069, China [6]Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, No. 8, Xi Tou Tiao, Youanmenwai Street, Fengtai District, Beijing 100069, China [7]Inner Mongolia Institute of Digestive Diseases, The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China [8]Department of Medical Risk Management, The Fifth Medical Center of PLA General Hospital, Beijing, China [9]Department of Liver Diseases, The Second Hospital of Nanjing, Affiliated to Nanjing University of Traditional Chinese Medicine, No. 1‑1 Zhongfu Road, Gulou District, Nanjing 210003, China [10]Peking University 302 Clinical Medical School, Beijing 100039, China
出处：
DOI： 10.1007/s12072-023-10541-w
ISSN：

关键词： Acute liver failure Drug-induced liver injury Transplant-free survival Hepatic encephalopathy

摘要：
There is growing recognition of natural history, complications, and outcomes of patients who develop non-acetaminophen (APAP) drug-induced acute liver failure (ALF). To clarify high-risk factors and develop a nomogram model to predict transplant-free survival (TFS) in patients with non-APAP drug-induced ALF.Patients with non-APAP drug-induced ALF from 5 participating centers were retrospectively analyzed. The primary endpoint was 21-day TFS. Total sample size was 482 patients.Regarding causative agents, the most common implicated drugs were herbal and dietary supplements (HDS) (57.0%). The hepatocellular type (R ≥ 5) was the main liver injury pattern (69.0%). International normalized ratio, hepatic encephalopathy grades, the use of vasopressor, N-acetylcysteine, or artificial liver support system were associated with TFS and incorporated to construct a nomogram model (drug-induced acute liver failure-5, DIALF-5). The AUROC of DIALF-5 for 7-day, 21-day, 60-day, and 90-day TFS in the internal cohort were 0.886, 0.915, 0.920, and 0.912, respectively. Moreover, the AUROC of DIALF-5 for 21-day TFS had the highest AUROC, which was significantly higher than 0.725 of MELD and 0.519 of KCC (p < 0.05), numerically higher than 0.905 of ALFSG-PI but without statistical difference (p > 0.05). These results were successfully validated in the external cohort (147 patients).Based on easily identifiable clinical data, the novel DIALF-5 model was developed to predict transplant-free survival in non-APAP drug-induced ALF, which was superior to KCC, MELD and had a similar prediction performance to ALFSG-PI but is more convenient, which can directly calculate TFS at multiple time points.© 2023. The Author(s).

基金：
This work was supported by the 302 Hospital Foundation (no. YNKTZ2018001), National Natural Science Foundation of China (Nos. 82070584, 81600453), Beijing Nova Program (no. Z171100001117114), and the Capital Characteristic Clinic Project by Beijing Municipal Science and Technology Commission (no. Z181100001718034). This sponsor had no role in study design, collection, analysis, and interpretation of data.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 胃肠肝病学
最新[2025]版：
大类 | 1 区 医学
小类 | 2 区 胃肠肝病学
第一作者：
第一作者机构： [1]Senior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing 100039, China
通讯作者：
通讯机构： [1]Senior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing 100039, China [3]Southeast University School of Medicine, No. 87 Dingjiaqiao Road, Gulou District, Nanjing 210003, China [4]The Second Hospital of Nanjing, Teaching Hospital of Southeast University, No. 1‑1 Zhongfu Road, Gulou District, Nanjing 210003, China [5]Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmenwai Street, Fengtai District, Beijing 100069, China [6]Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, No. 8, Xi Tou Tiao, Youanmenwai Street, Fengtai District, Beijing 100069, China [9]Department of Liver Diseases, The Second Hospital of Nanjing, Affiliated to Nanjing University of Traditional Chinese Medicine, No. 1‑1 Zhongfu Road, Gulou District, Nanjing 210003, China [10]Peking University 302 Clinical Medical School, Beijing 100039, China
推荐引用方式(GB/T 7714)：
Lin Han,Ang Huang,Jinjun Chen,et al.Clinical characteristics and prognosis of non-APAP drug-induced acute liver failure: a large multicenter cohort study[J].Hepatology international.2023,doi:10.1007/s12072-023-10541-w.
APA：
Lin Han,Ang Huang,Jinjun Chen,Guangju Teng,Ying Sun...&Zhengsheng Zou.(2023).Clinical characteristics and prognosis of non-APAP drug-induced acute liver failure: a large multicenter cohort study.Hepatology international,,
MLA：
Lin Han,et al."Clinical characteristics and prognosis of non-APAP drug-induced acute liver failure: a large multicenter cohort study".Hepatology international .(2023)

相关文献

[1]Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update [2]Prediction of biochemical nonresolution in patients with chronic drug-induced liver injury: A large multicenter study. [3]Prediction of Biochemical Nonresolution in Patients with Chronic Drug-induced Liver Injury: A Large Multicenter Study. [4](+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis. [5]扶正养肝合剂对药物性肝损伤的保护作用研究 [6]A bioartificial transgenic porcine whole liver expressing human proteins alleviates acute liver failure in pigs [7]Advances in cell death - related signaling pathways in acute-on-chronic liver failure. [8]Niujiaodihuang Detoxify Decoction inhibits ferroptosis by enhancing glutathione synthesis in acute liver failure models. [9]Advances in cell death - related signaling pathways in acute-on-chronic liver failure. [10]Mitochondrial Damage and Drp1 Overexpression in Rifampicin- and Isoniazid-induced Liver Injury Cell Model.

资源点击量：2018 今日访问量：0 总访问量：645 更新日期：2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持：重庆聚合科技有限公司 地址：广州市越秀区大德路111号