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Potential mechanisms underlying the therapeutic roles of Gancao Fuzi decoction in cold-dampness obstruction syndrome-type knee osteoarthritis

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收录情况： ◇ SCIE

作者：
Zhao Jinlong[1,2,3] * ; Liang Guihong[1,2,3] ; Huang Hetao[2] ; Yang Weiyi[2] ; Pan Jianke[2] ; Luo Minghui[2] ; Zeng Lingfeng[1,2,3,*1,*2,*3] ; Liu Jun[3,4,5,*3,*4,*5] ;
机构： [1]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China [2]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, 510120, China [3]The Research Team on Bone and Joint Degeneration and Injury of Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120, China [4]The Fifth Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China [5]Guangdong Second Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, 510095, China
出处：
DOI： 10.2174/1573409919666230605115940
ISSN：

关键词： Network pharmacology Gancao fuzi decoction cold-dampness obstruction syndrome knee osteoarthritis action mechanism molecular mechanism

摘要：
The key active components and potential molecular mechanism of Gancao Fuzi decoction (GFD) in the treatment of cold-dampness obstruction-type knee osteoarthritis (KOA) remain unclear.To explore the mechanism of GFD in the treatment of cold-dampness obstruction syndrome-type KOA by network pharmacology. Methods The potential active components and targets of the four herbs in GFD (Fuzi, Guizhi, Baizhu, and Gancao) were screened using the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. The targets of KOA were obtained with the Comparative Toxicogenomics Database (CTD), the GeneCards database, and the DisGeNET database, and the common targets of the drugs and disease were ultimately obtained. Cytoscape (v.3.7.1) was used to draw the active component-target network, and the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) (v.11.0) database was used to construct the protein interaction network. The Database for Annotation, Visualization, and Integrated Discovery (DAVID) was used for the Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of the intersecting targets. Results A total of 102 potential active components and 208 targets of GFD in the treatment of cold-dampness obstruction syndrome-type KOA were screened. GFD treatment was found to be closely related to many inflammatory signalling pathways in the treatment of KOA. Conclusion The effect of GFD on cold-dampness obstruction syndrome-type KOA is mediated by multicomponent, multitarget, and multichannel mechanisms, which provides the basis for further experimental study of its pharmacodynamic material basis and mechanism.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

基金：
This work was supported by the Science and Technology Program of Guangzhou (Grant No: 202102010273), a Special project of the State Key Laboratory of Dampness Syndrome of Chinese Medicine & the Project of Administration of Traditional Chinese Medicine of Guangdong Province (Grant No: 20225025, Grant No: 20225016, Grant No: 20231109), the National Natural Science Foundation of China (Grant No: 82004386), Guangdong Basic and Applied Basic Research Foundation (Grant No: 2022A1515220131, Grant No: 2022A1515010385, Grant No: 2022A1515011700), Foreign Teacher Programs of Guangdong Provincial Department of Science and Technology (YKZZ[2022]No.232), and the Science and Technology Research Project of Guangdong Provincial Hospital of Chinese Medicine (No. YN2019 ML08, No. YN2022GK05, No. YN2020MS16).
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 4 区 医学
小类 | 4 区 药物化学 4 区 计算机：跨学科应用
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 药物化学 4 区 计算机：跨学科应用
JCR分区：
出版当年[2022]版：
Q4 CHEMISTRY, MEDICINAL Q4 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS
最新[2023]版：
Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS Q4 CHEMISTRY, MEDICINAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China [2]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, 510120, China [3]The Research Team on Bone and Joint Degeneration and Injury of Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120, China
通讯作者：
通讯机构： [1]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China [2]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, 510120, China [3]The Research Team on Bone and Joint Degeneration and Injury of Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120, China [4]The Fifth Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China [5]Guangdong Second Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, 510095, China [*1]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, China [*2]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510120, China [*3]The Research Team on Bone and Joint Degeneration and Injury of Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510120, China [*4]The Fifth Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, China [*5]Guangdong Second Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou 510095, China
推荐引用方式(GB/T 7714)：
Zhao Jinlong,Liang Guihong,Huang Hetao,et al.Potential mechanisms underlying the therapeutic roles of Gancao Fuzi decoction in cold-dampness obstruction syndrome-type knee osteoarthritis[J].CURRENT COMPUTER-AIDED DRUG DESIGN.2024,20(4):384-395.doi:10.2174/1573409919666230605115940.
APA：
Zhao Jinlong,Liang Guihong,Huang Hetao,Yang Weiyi,Pan Jianke...&Liu Jun.(2024).Potential mechanisms underlying the therapeutic roles of Gancao Fuzi decoction in cold-dampness obstruction syndrome-type knee osteoarthritis.CURRENT COMPUTER-AIDED DRUG DESIGN,20,(4)
MLA：
Zhao Jinlong,et al."Potential mechanisms underlying the therapeutic roles of Gancao Fuzi decoction in cold-dampness obstruction syndrome-type knee osteoarthritis".CURRENT COMPUTER-AIDED DRUG DESIGN 20..4(2024):384-395

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