个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

NLRP3 inflammasome-mediated Pyroptosis induce Notch signal activation in endometriosis angiogenesis

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Zhang Minyi[1] * ; Shi Zhimian[1] * ; Peng Xianglan[2] * ; Cai Dongpeng[1] ; Peng Rui[2] ; Lin Yike[1] ; Dai Linfeng[1] ; Li Jieyi[1] ; Chen Yulin[1] ; Xiao Jing[3] ; Dong Su[4] ; Wang Wei[1,*2] ; Chen Yang[1,*2] ; He Hong[2,*1] ;
机构： [1]Department of Pharmacology, School of Chinese Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China [2]Department of Obstetrics and Gynecology, Department of Gynecologic Oncology Research Office, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, Guangdong, China [3]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, Guangdong, China [4]Department of Pharmacy, People’s Hospital of Dongxihu District, Wuhan, 430040, Hubei, China
出处：
DOI： 10.1016/j.mce.2023.111952
ISSN：

关键词： Endometriosis NLRP3 inflammasome Angiogenesis Pyroptosis Notch1 signal

摘要：
Endometriosis is characterized by the presence of endometrial tissue outside the uterus that not only causes severe pelvic pain and infertility but also increased risk for ovarian carcinogenesis in women of reproductive age. Here, we found that angiogenesis was increased and accompanied with up-regulation of Notch1 in human endometriotic tissue sample, which is associated with pyroptosis induced by activation of endothelial NLRP3 inflammasome. Further, in endometriosis model induced in wild type and NLRP3-deficient (NLRP3-KO) mice, we found that deficiency of NLRP3 suppressing the development of endometriosis. In vitro, inhibiting the activation of NLRP3 inflammasome prevents LPS/ATP-induced tube formation in endothelial cells. Meanwhile, knockdown NLRP3 expression by gRNA disrupt the interaction between Notch1 and HIF-1α under the inflammatory microenvironment. This study demonstrates that activation of NLRP3 inflammasome-mediated pyroptosis affects angiogenesis in endometriosis via Notch1-dependent manner.Copyright © 2023 Elsevier B.V. All rights reserved.

基金：
This work was supported by the National Natural Science Foundation of China (81701415); the National Natural Science Foundation of China (82274130); the Guangdong Natural Science Funds for Distinguished Young Scholars [Grant number 2018B030306027]; the Basic Research Project of Guangdong Province [Grant number 2018A030310622]; the Major Program of Science and Technology Program of Guangzhou [Grant number 202103000044]; Key Research Program of Guangdong Province [2018KZDXM023]; the Wuhan Health Science Foundation [Grant number WZ20Y03]; the Basic Research Project of Guangzhou [Grant number 202102010285].
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 3 区 细胞生物学 3 区 内分泌学与代谢
最新[2025]版：
大类 | 2 区 医学
小类 | 3 区 细胞生物学 3 区 内分泌学与代谢
JCR分区：
出版当年[2021]版：
Q2 ENDOCRINOLOGY & METABOLISM Q3 CELL BIOLOGY
最新[2023]版：
Q2 CELL BIOLOGY Q2 ENDOCRINOLOGY & METABOLISM

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Pharmacology, School of Chinese Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Pharmacology, School of Chinese Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China [2]Department of Obstetrics and Gynecology, Department of Gynecologic Oncology Research Office, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, Guangdong, China [*1]Department of Gynaecology and Obstetrics, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, No.63 Duobao Street, Liwan District, Guangzhou, 510150, Guangdong, China. [*2]School of Pharmaceutical, Guangzhou University of Chinese Medicine, No.232, Waihuan East Road, Guangzhou Higher Education Mega Centre Mega Centre, Panyu District, Guangzhou, 510006, Guangdong, China.
推荐引用方式(GB/T 7714)：
Zhang Minyi,Shi Zhimian,Peng Xianglan,et al.NLRP3 inflammasome-mediated Pyroptosis induce Notch signal activation in endometriosis angiogenesis[J].MOLECULAR AND CELLULAR ENDOCRINOLOGY.2023,574:doi:10.1016/j.mce.2023.111952.
APA：
Zhang Minyi,Shi Zhimian,Peng Xianglan,Cai Dongpeng,Peng Rui...&He Hong.(2023).NLRP3 inflammasome-mediated Pyroptosis induce Notch signal activation in endometriosis angiogenesis.MOLECULAR AND CELLULAR ENDOCRINOLOGY,574,
MLA：
Zhang Minyi,et al."NLRP3 inflammasome-mediated Pyroptosis induce Notch signal activation in endometriosis angiogenesis".MOLECULAR AND CELLULAR ENDOCRINOLOGY 574.(2023)

相关文献

[1]TREM2/β-catenin attenuates NLRP3 inflammasome-mediated macrophage pyroptosis to promote bacterial clearance of pyogenic bacteria [2]Silibinin ameliorates deoxycholic acid-induced pyroptosis in steatotic HepG2 cells by inhibiting NLRP3 inflammasome activation [3]TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells [4]Xiaoqinglong decoction improves allergic rhinitis by inhibiting NLRP3-mediated pyroptosis in BALB/C mice [5]The marine Penicillium sp. GGF16-1-2 metabolite dicitrinone G inhibits pancreatic angiogenesis by regulating the activation of NLRP3 inflammasome [6]Deoxycholic Acid Promotes Pyroptosis in Free Fatty Acid-Induced Steatotic Hepatocytes by Inhibiting PINK1-Mediated Mitophagy. [7]Andrade-Oliveira Salvianolic Acid B Modulates Caspase-1-Mediated Pyroptosis in Renal Ischemia-Reperfusion InjuryviaNrf2 Pathway [8]Schisandrin A regulates the Nrf2 signaling pathway and inhibits NLRP3 inflammasome activation to interfere with pyroptosis in a mouse model of COPD [9]NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis [10]蠲痹汤对痛风湿热瘀阻证老年患者NLRP3炎性体的影响

资源点击量：2022 今日访问量：0 总访问量：648 更新日期：2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持：重庆聚合科技有限公司 地址：广州市越秀区大德路111号