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Xiaoqinglong decoction improves allergic rhinitis by inhibiting NLRP3-mediated pyroptosis in BALB/C mice

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收录情况： ◇ SCIE

作者：
Wang Ruizhi[1] * ; Wang Yongchun[1] ; Yang Qintai[1,5] ; Liu Jiaming[6] ; Lu Zesheng[1] ; Xu Weizhen[1] ; Zhu Jinxiang[1] ; Liu He[1] ; He Weiping[2,3] ; Yan Yajie[2,3,*3] ; Ruan Yan[2,3,*2] ; Zhou Min[1,2,5,*1] ;
机构： [1]The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou 510405, China [2]Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China [3]Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou 510405, China [4]Department of Otolaryngology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510000, China [5]Department of Allergy, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510000, China [6]The Second Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou 510405, China
出处：
DOI： 10.1016/j.jep.2023.117490
ISSN：

关键词： Xiaoqinglong decoction Allergic rhinitis NLRP3 inflammasome Gasdermin D Pyroptosis

摘要：
Xiaoqinglong decoction (XQLD), first recorded in Shang Han Lun, is a traditional Chinese medicine prescribed for the treatment of allergic rhinitis (AR). XQLD alleviates the clinical symptoms of AR by inhibiting the occurrence of an inflammatory response, but the specific regulatory mechanism remains unclear.NLRP3-mediated pyroptosis is closely related to AR pathogenesis. Hence, this study aimed to explore the potential role of NLRP3-mediated pyroptosis pathway in the AR-associated pharmacological mechanism of XQLD.BALB/C mice models of AR was established by using ovalbumin (OVA) and aluminum hydroxide sensitization. After intragastric administration of different dosages of XQLD, nasal allergic symptoms were observed. The expression of OVA-sIgE and Th2 inflammatory factors (IL-4, IL-5, and IL-13) in serum was detected by ELISA. The histopathological morphology and expression of inflammatory factors in nasal mucosa along with pyroptosis were investigated. Molecular docking was performed to analyze the binding of representative compounds of XQLD with NLRP3. Activation of the NLRP3 inflammasome was detected by immunofluorescence and western blotting.XQLD significantly improved the nasal allergic symptoms of mice, reduced the degree of goblet cell proliferation, mast cell infiltration, and collagen fiber hyperplasia in nasal mucosa. Meanwhile, it could downregulate the expression of Th2 inflammatory factors (IL-4, IL-5, and IL-13) in serum and nasal mucosa. XQLD significantly reduced the number of GSDMD and TUNEL double-positive cells and IL-1β and IL-18 expression. Molecular docking confirmed that seven representative compounds of XQLD had good binding properties with NLRP3 and were able to inhibit the activation of the NLRP3 inflammasome.The representative compounds of XQLD might inhibit pyroptosis in nasal mucosa mediated by the NLRP3 inflammasome to helping the recovery of AR, which provides a new modern pharmacological proof for XQLD to treat AR.Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

基金：
This research was funded by a grant from the National Natural Science Foundation of China (No.82274590, No.82305325, No.81974581), Basic and Applied Research Foundation of Guangdong Province, China (No.2021A1515110446), Guangzhou Science and Technology Project (No.2022-01-01-11-3016-0012), Science and Technology Basic and Applied Basic Research Project of Guangzhou (No.202201011211), Guangzhou Science and Technology Planning Project (No.202201020308), and National natural science foundation of key support project (No.U20A20399).
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外文
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出版当年[2023]版：
大类 | 2 区 医学
小类 | 1 区 药物化学 1 区 全科医学与补充医学 1 区 药学 1 区 植物科学
最新[2025]版：
大类 | 2 区 医学
小类 | 1 区 全科医学与补充医学 1 区 药学 2 区 药物化学 2 区 植物科学
JCR分区：
出版当年[2022]版：
Q1 CHEMISTRY, MEDICINAL Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Q1 PHARMACOLOGY & PHARMACY Q1 PLANT SCIENCES
最新[2023]版：
Q1 CHEMISTRY, MEDICINAL Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Q1 PHARMACOLOGY & PHARMACY Q1 PLANT SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou 510405, China
通讯作者：
通讯机构： [1]The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou 510405, China [2]Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China [3]Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou 510405, China [5]Department of Allergy, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510000, China [*1]The First Clinical Medical School of Guangzhou University of Chinese Medicine. No.12 of Jichang Road, Baiyun District, Guangzhou 510405, China. [*2]Corresponding author. Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine. No.16 of Jichang Road, Baiyun District, Guangzhou 510405, China [*3]Corresponding author. Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine. No.16 of Jichang Road, Baiyun District, Guangzhou 510405, China
推荐引用方式(GB/T 7714)：
Wang Ruizhi,Wang Yongchun,Yang Qintai,et al.Xiaoqinglong decoction improves allergic rhinitis by inhibiting NLRP3-mediated pyroptosis in BALB/C mice[J].JOURNAL OF ETHNOPHARMACOLOGY.2024,321:doi:10.1016/j.jep.2023.117490.
APA：
Wang Ruizhi,Wang Yongchun,Yang Qintai,Liu Jiaming,Lu Zesheng...&Zhou Min.(2024).Xiaoqinglong decoction improves allergic rhinitis by inhibiting NLRP3-mediated pyroptosis in BALB/C mice.JOURNAL OF ETHNOPHARMACOLOGY,321,
MLA：
Wang Ruizhi,et al."Xiaoqinglong decoction improves allergic rhinitis by inhibiting NLRP3-mediated pyroptosis in BALB/C mice".JOURNAL OF ETHNOPHARMACOLOGY 321.(2024)

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