机构：[1]Guangdong Provincial Key Laboratory of Translational Cancer Research of Chinese Medicines, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China[2]Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510000, People’s Republic of China广东省中医院
Two previously undescribed phloroglucinol derivatives [(±) evolephloroglucinols A and B], five unusual coumarins [evolecoumarins A and B and (±) evolecoumarins C–E], and one novel enantiomeric quinoline-type
alkaloid [(±) evolealkaloid A], along with 20 known compounds, were isolated from the EtOH extract of the
roots of Evodia lepta Merr. Their structures were elucidated by extensive spectroscopic analyses. The absolute
configurations of the undescribed compounds were determined by X-ray diffraction or computational calculations. Their anti-neuroinflammatory effects were assayed. Among the identified compounds, compound 5a
effectively reduced nitric oxide (NO) production with an EC50 value of 22.08 ± 0.46 μM. Hence, it could indeed
inhibit the lipopolysaccharide (LPS)-induced Nod-like receptor family, pyrin domain containing 3 (NLRP3)
inflammasome
基金：
Natural Science Foundation of Guangdong Province of China (No. 2022A1515011212), National Natural
Science Foundation of China (No. 81930114), Key-Area Research and
Development Program of Guangdong Province (No.
2020B1111100004), Key Laboratory of Guangdong Drug Administration (2021ZDB03).
第一作者机构：[1]Guangdong Provincial Key Laboratory of Translational Cancer Research of Chinese Medicines, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Ding Xiao-Ying,Wen Jun-Ru,Lin Wei-Yao,et al.Phloroglucinol derivatives, coumarins and an alkaloid from the roots of Evodia lepta Merr[J].PHYTOCHEMISTRY.2023,213:doi:10.1016/j.phytochem.2023.113774.
APA：
Ding Xiao-Ying,Wen Jun-Ru,Lin Wei-Yao,Huang Guo-Yong,Feng Qian...&Wang Ying.(2023).Phloroglucinol derivatives, coumarins and an alkaloid from the roots of Evodia lepta Merr.PHYTOCHEMISTRY,213,
MLA：
Ding Xiao-Ying,et al."Phloroglucinol derivatives, coumarins and an alkaloid from the roots of Evodia lepta Merr".PHYTOCHEMISTRY 213.(2023)
