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Undescribed phloroglucinol derivatives with antiviral activities from Dryopteris atrata (Wall. Ex Kunze) Ching

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资源类型：
Pubmed体系：
作者：
Zhang Ji-Hui[1] * ; Chen Jin-Lin[1] * ; Xu Wei-Bin[1] ; Xia Yi-Ping[1,5] ; Zhu Hao-Yue[1] ; Wang Jing-Hao[2,3] ; Li Yao-Lan[1] ; Wang Guo-Cai[1,3,*3] ; Zhang Yu-Bo[3,4,*2] ; Chen Neng-Hua[2,3,*1] ;
机构： [1]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China [2]Department of Pharmacy, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China [3]The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, Jinan University, Guangzhou, 510630, China [4]Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, 510632, China [5]Department of Dermatology, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde Foshan), Foshan, 528308, China
出处：
DOI： 10.1016/j.phytochem.2023.113585
ISSN：

关键词： Dryopteris atrata Dryopteridaceae Phloroglucinol derivatives Structural elucidation Antiviral activities

摘要：
Nine undescribed phloroglucinol derivatives (dryatraols A-I) with five different backbones and three known dimeric acylphloroglucinols were isolated from the rhizome of Dryopteris atrata (Wall. Ex Kunze) Ching (Dryopteridaceae). Dryatraol A contains an unprecedented carbon skeleton-a butyrylphloroglucinol and a rulepidanol-type sesquiterpene are linked via a furan ring to form a 6/5/6/6 ring system. Dryatraols B and C are the first examples of monomeric phloroglucinols coupled with the aristolane-type sesquiterpene through the C-C bond. Dryatraol D features a rare spiro [benzofuran-2',5″-furan] backbone. Dryatraols E-I are five undescribed adducts with a butyrylphloroglucinol or filicinic acid incorporated into the germacrene-type sesquiterpene via a pyran ring. These undescribed structures were determined by comprehensively analysing the spectroscopic data, X-ray diffraction results, and electronic circular dichroism calculations. The result of in vitro antiviral activity evaluation indicated that dryatraol C displayed the strongest antiviral effect against both respiratory syncytial virus and influenza A virus (H1N1), with IC50 values of 11.9 μM and 5.5 μM, respectively. Dryatraols F-H exhibited considerable inhibitory activity against herpes simplex virus type 1 (HSV-1), with IC50 values ranging from 2.6 to 6.3 μM. Analysis of the inhibitory mechanism using a time-of-addition assay revealed that dryatraol G may inhibit the replication of HSV-1 by interfering with the late stage of the viral life cycle.Copyright © 2023. Published by Elsevier Ltd.

基金：
This work was supported by grants from the National Natural Science Foundation of China (Nos. 82173695, 82003609, 82003743, 82104015), the Guangdong Basic and Applied Basic Research Foundation (Nos. 2020A1515110453, 2020A1515110415), China Postdoctoral Science Foundations (Nos. 2019M663403, 2021M691261), Foshan Science and Technology Burea (No. FS0AA-KJ218-1301-0013), and the high performance public computing service platform of Jinan University.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 生物学
小类 | 2 区 植物科学 2 区 生化与分子生物学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 植物科学
第一作者：
第一作者机构： [1]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China
共同第一作者：
通讯作者：
通讯机构： [1]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, China [2]Department of Pharmacy, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China [3]The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, Jinan University, Guangzhou, 510630, China [4]Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, 510632, China [*1]The First Affiliated Hospital, Jinan University, 613 Huangpu Avenue West, Guangzhou, 510630, China. [*2]Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Guangzhou, 510630, China [*3]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, 510630, China
推荐引用方式(GB/T 7714)：
Zhang Ji-Hui,Chen Jin-Lin,Xu Wei-Bin,et al.Undescribed phloroglucinol derivatives with antiviral activities from Dryopteris atrata (Wall. Ex Kunze) Ching[J].Phytochemistry.2023,113585.doi:10.1016/j.phytochem.2023.113585.
APA：
Zhang Ji-Hui,Chen Jin-Lin,Xu Wei-Bin,Xia Yi-Ping,Zhu Hao-Yue...&Chen Neng-Hua.(2023).Undescribed phloroglucinol derivatives with antiviral activities from Dryopteris atrata (Wall. Ex Kunze) Ching.Phytochemistry,,
MLA：
Zhang Ji-Hui,et al."Undescribed phloroglucinol derivatives with antiviral activities from Dryopteris atrata (Wall. Ex Kunze) Ching".Phytochemistry .(2023):113585

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