机构：[1]The First Clinical College, Guangdong Medical University, Zhanjiang, Guangdong, China.[2]Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.[3]Animal Experiment Center, Guangdong Medical University, Zhanjiang, China.[4]The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong, China.[5]The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, Guangdong, China.
Ferroptosis, a type of cell death involving iron and lipid peroxidation, has been found to be closely associated with the development of many diseases. Mitochondria are vital components of eukaryotic cells, serving important functions in energy production, cellular metabolism, and apoptosis regulation. Presently, the precise relationship between mitochondria and ferroptosis remains unclear. In this study, we aim to systematically elucidate the mechanisms via which mitochondria regulate ferroptosis from multiple perspectives to provide novel insights into mitochondrial functions in ferroptosis. Additionally, we present a comprehensive overview of how mitochondria contribute to ferroptosis in different conditions, including cancer, cardiovascular disease, inflammatory disease, mitochondrial DNA depletion syndrome, and novel coronavirus pneumonia. Gaining a comprehensive understanding of the involvement of mitochondria in ferroptosis could lead to more effective approaches for both basic cell biology studies and medical treatments.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|1 区医学
小类|1 区老年医学
最新[2025]版：
大类|3 区医学
小类|3 区老年医学
第一作者：
第一作者机构：[1]The First Clinical College, Guangdong Medical University, Zhanjiang, Guangdong, China.
通讯作者：
通讯机构：[4]The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong, China.[5]The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, Guangdong, China.[*1]The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
推荐引用方式(GB/T 7714)：
Feng Fuhai,He Shasha,Li Xiaoling,et al.Mitochondria-mediated Ferroptosis in Diseases Therapy: From Molecular Mechanisms to Implications[J].Aging and disease.2023,doi:10.14336/AD.2023.0717.
APA：
Feng Fuhai,He Shasha,Li Xiaoling,He Jiake&Luo Lianxiang.(2023).Mitochondria-mediated Ferroptosis in Diseases Therapy: From Molecular Mechanisms to Implications.Aging and disease,,
MLA：
Feng Fuhai,et al."Mitochondria-mediated Ferroptosis in Diseases Therapy: From Molecular Mechanisms to Implications".Aging and disease .(2023)
医学