机构：[1]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical, University of Macau, Macao, China.[2]Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai 519000, China.[3]Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Macao, China.[4]MoE Frontiers Science Center for Precision Oncology, University of Macau, Macao, China.[5]GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Disease, Guangzhou Medical University, Guangzhou 511436, China.
Napabucasin (also known as BBI608) is a natural naphthoquinone originally identified as a cancer cell stemness inhibitor. Accumulated in vitro and in vivo evidence demonstrated that napabucasin showed significant anticancer effects in various types of cancers. Napabucasin inhibits cancer cell proliferation, induces apoptosis and cell cycle arrest, and suppresses metastasis and relapse. Such anticancer activities of napabucasin mainly rely on the inhibition of cancer stemness by targeting signal transducer and activator of transcription 3 (STAT3) and its related gene inhibition. However, several novel molecular targets for napabucasin, such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and thioredoxin reductase 1 (TrxR1), have been reported. Napabucasin represents a promising anticancer lead for multiple cancers. In this mini review, the anticancer potential and the molecular mechanism of napabucasin will be briefly highlighted.
基金：
Science and Technology Development Fund of Macau SAR
(0070/2022/A2) and the Science and Technology Planning Project of Zhuhai City of China (grant
number 20191206F060001).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|2 区化学
小类|3 区化学：综合3 区生化与分子生物学
最新[2025]版：
大类|3 区化学
小类|3 区生化与分子生物学3 区化学：综合
第一作者：
第一作者机构：[1]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical, University of Macau, Macao, China.
通讯作者：
通讯机构：[1]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical, University of Macau, Macao, China.[3]Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Macao, China.[4]MoE Frontiers Science Center for Precision Oncology, University of Macau, Macao, China.[5]GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Disease, Guangzhou Medical University, Guangzhou 511436, China.
推荐引用方式(GB/T 7714)：
Shao Zeyang,Wang Heng,Ren Haiyan,et al.The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone[J].Molecules (Basel, Switzerland).2023,28(15):doi:10.3390/molecules28155678.
APA：
Shao Zeyang,Wang Heng,Ren Haiyan,Sun Yinxiang&Chen Xiuping.(2023).The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone.Molecules (Basel, Switzerland),28,(15)
MLA：
Shao Zeyang,et al."The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone".Molecules (Basel, Switzerland) 28..15(2023)
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