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STAT3 exerts pro-tumor and anti-autophagy roles in cervical cancer.

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wu Lin[1,2] * ; Shen Bowen[3] * ; Li Junpeng[2] * ; Zhang Huirong[4] ; Zhang Ke[1,2] ; Yang Yao[5] ; Zu Zhenyu[2] ; Shen Dongxiang[6] ; Luo Min[1,2] ;
机构： [1]The First School of Clinical Medicine, Southern Medical University,Guangzhou, China [2]Department of Obstetrics and Gynecology, GeneralHospital of Southern Theatre Command of PLA, Guangzhou, China [3]Department of Clinical Medicine, Zhongshan Medical College of SunYat-sen University, Guangzhou, China [4]Department of Gynecology, theSecond Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou, China [5]Department of Obstetrics and Gynecology, the thirdaffiliated hospital of Guangzhou medical university, Guangzhou, China [6]Department of Medical Engineering, General Hospital of Southern TheatreCommand of PLA, Guangzhou, China
出处：
DOI： 10.1186/s13000-021-01182-4
ISSN：

关键词： Cervical cancer Autophagy STAT3 LC3B

摘要：
STAT3 plays an important role in cervical cancer. LC3B, the most potential molecular biomarker of autophagy that may promote or inhibit cancer progression, can be downregulated by STAT3. However the role of STAT3 in the autophagy of cervical cancer remains unclear.This study aimed to evaluate the relationship between STAT3 and LC3B in protein level, and verify whether STAT3 promotes proliferation, migration and plate colony formation by inhibiting autophagy of cervical cancer cells through bcl2-beclin1 axis.STAT3 was overexpressed in cervical cancer tissues, and negatively correlated with the expression level of LC3B. STAT3 knockout or knockdown significantly increased the autophagy level and decreased proliferation, migration, plate colony formation and subcutaneous tumorigenesis of cervical cancer cells in vitro and in vivo. STAT3 is known to mediate autophagy through Bcl2-Beclin1 complex. Bcl2 was positively whereas Beclin1 negatively correlated with STAT3 expression, indicating that Bcl2-Beclin1 complex involved in this transition.STAT3 may upregulate the autophagy level of cervical cancer cells through the Bcl2-Beclin1 axis. This indicates that STAT3 may be an important prognostic and therapeutic target for cervical cancer.© 2021. The Author(s).

基金：
Natural Science Foundation of Guangdong Province [grant number 2020A1515010236].
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 4 区 医学
小类 | 4 区 病理学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 病理学
JCR分区：
出版当年[2020]版：
Q3 PATHOLOGY
最新[2023]版：
Q2 PATHOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]The First School of Clinical Medicine, Southern Medical University,Guangzhou, China [2]Department of Obstetrics and Gynecology, GeneralHospital of Southern Theatre Command of PLA, Guangzhou, China
共同第一作者：
通讯作者：
通讯机构： [1]The First School of Clinical Medicine, Southern Medical University,Guangzhou, China [2]Department of Obstetrics and Gynecology, GeneralHospital of Southern Theatre Command of PLA, Guangzhou, China
推荐引用方式(GB/T 7714)：
Wu Lin,Shen Bowen,Li Junpeng,et al.STAT3 exerts pro-tumor and anti-autophagy roles in cervical cancer.[J].DIAGNOSTIC PATHOLOGY.2022,17(1):doi:10.1186/s13000-021-01182-4.
APA：
Wu Lin,Shen Bowen,Li Junpeng,Zhang Huirong,Zhang Ke...&Luo Min.(2022).STAT3 exerts pro-tumor and anti-autophagy roles in cervical cancer..DIAGNOSTIC PATHOLOGY,17,(1)
MLA：
Wu Lin,et al."STAT3 exerts pro-tumor and anti-autophagy roles in cervical cancer.".DIAGNOSTIC PATHOLOGY 17..1(2022)

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