机构：[1]Department of Anesthesiology, Guangudong Provincal Hospital of TCM,Guangzhou, Guangdong 510120, P.R.China[2]Department of Anesthesiology, Tongi Hospital, Tongji Medical College, Huazhong Universiny of Science & Technology,Wuhan,Hubei 430030,P.R.China
Objective To investigate the expression of Signal Transducers and Activators of Transcription 3 in the lumbar spinal cord induced by the tibial cancer pain in rats. Methods Twenty SD female rats weighing 180~220g were randomly divided into 2 groups (n=10 each). Model group: intra-tibial injection of 3 μL MADB-106 mammary gland carcinoma cells of rats (4.8ence micrographs demonstrated that antibodies againsted STAT3 and the astrocyte marker GFAP labeled the same cell. Conclusion Taken together, our studies indicate that STAT3 in spinal cord is involved in the generation and maintenance of bone cancer pain states, and the astrocytes in spinal cord participate in the development of bone cancer pain via the JAK/STAT3 pathway.
基金：
Supported by the Science Research Innovation Foundation of Guangzhou University Of TCM(No．2005C050)
语种：
外文
第一作者：
第一作者机构：[1]Department of Anesthesiology, Guangudong Provincal Hospital of TCM,Guangzhou, Guangdong 510120, P.R.China
推荐引用方式(GB/T 7714)：
XIANG Hong-bing,XIAO Jian-bin,ZHAO Wei-xian,et al.骨癌痛模型大鼠患侧腰段脊髓STAT3的表达及其意义[J].CHINA JOURNAL OF MODERN MEDICINE.2008,18(9):1158-1161.doi:10.3969/j.issn.1005-8982.2008.09.002.
APA：
XIANG Hong-bing,XIAO Jian-bin,ZHAO Wei-xian&DONG Hang.(2008).骨癌痛模型大鼠患侧腰段脊髓STAT3的表达及其意义.CHINA JOURNAL OF MODERN MEDICINE,18,(9)
MLA：
XIANG Hong-bing,et al."骨癌痛模型大鼠患侧腰段脊髓STAT3的表达及其意义".CHINA JOURNAL OF MODERN MEDICINE 18..9(2008):1158-1161
