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Lindenane sesquiterpenoid dimers from Chloranthus holostegius with anti-neuroinflammatory activities in BV-2 microglia

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资源类型：
Pubmed体系：
作者：
Zhan Zhao-Chun[1] * ; Xia Yi-Ping[1] * ; Tang Qing[1] * ; Zhu Hui-Hui[1] ; Du Jing-Yi[1] ; Cai Jun-Xing[1] ; Chen Yan-Jun[2] ; Wu Zhong-Nan[1] ; Li Yao-Lan[1] ; Chen Neng-Hua[3] ; Wang Guo-Cai[1] ; Zhang Yu-Bo[2] ;
机构： [1]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China [2]Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, 510632, PR China [3]Department of Pharmacy, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China
出处：
DOI： 10.1016/j.phytochem.2023.113859
ISSN：

关键词： Chloranthus holostegius Chloranthaceae Lindenane sesquiterpenoid dimer BV-2 microglial cell Anti-neuroinflammatory Nitric oxide

摘要：
Fifteen undescribed lindenane-type sesquiterpenoid dimers, designated chloranholides F-T (1-15), together with twenty-five known analogs (16-40), were isolated from the whole plants of Chloranthus holostegius. The isolate structures were elucidated by analysis of spectroscopic data and chemical methods, and their absolute configurations were determined by X-ray crystallography and electronic circular dichroism spectra. In anti-neuroinflammatory assays, all isolates were evaluated by examination of their inhibitory effect on nitric oxide (NO) in LPS-stimulated BV-2 cells, and the results showed that 21-24, 26, 30, 32 and 36 significantly inhibited the production of the inflammatory mediator NO, with IC50 values ranging from 3.18 to 11.46 μM, which was better than that of quercetin. Structure-activity relationship analysis revealed that two essential functional groups played an indispensable role in the anti-inflammatory effects. Moreover, 22 and 24 inhibited the LPS-induced upregulation of iNOS and COX-2 enzymes in BV-2 microglia at the protein level.Copyright © 2023. Published by Elsevier Ltd.

基金：
National Natural Science Foundation of China (Nos. 81973190, 82104015, 82273803), the Guangdong Basic and Applied Basic Research Foundation (Nos. 2019B1515120029, 2020B1515020033), the Science and Technology Planning Project of Guangzhou City (No. 202201010485), the Fundamental Research Funds for the Central Universities, analytical and testing center of Jinan University, and the high-performance public computing service platform of Jinan University.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 生物学
小类 | 2 区 植物科学 2 区 生化与分子生物学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 植物科学
第一作者：
第一作者机构： [1]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhan Zhao-Chun,Xia Yi-Ping,Tang Qing,et al.Lindenane sesquiterpenoid dimers from Chloranthus holostegius with anti-neuroinflammatory activities in BV-2 microglia[J].Phytochemistry.2023,215:113859.doi:10.1016/j.phytochem.2023.113859.
APA：
Zhan Zhao-Chun,Xia Yi-Ping,Tang Qing,Zhu Hui-Hui,Du Jing-Yi...&Zhang Yu-Bo.(2023).Lindenane sesquiterpenoid dimers from Chloranthus holostegius with anti-neuroinflammatory activities in BV-2 microglia.Phytochemistry,215,
MLA：
Zhan Zhao-Chun,et al."Lindenane sesquiterpenoid dimers from Chloranthus holostegius with anti-neuroinflammatory activities in BV-2 microglia".Phytochemistry 215.(2023):113859

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