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The critical role of platelet in cancer progression and metastasis

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机构: [1]Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA [2]Department of Gastrointestinal Surgery, Huizhou Municipal Central Hospital, Huizhou, Guangdong 516001, People’s Republic of China [3]Department of Oncology, Zhoushan Hospital of Traditional Chinese Medicine (Afliated to Zhejiang University of Traditional Chinese Medicine), Zhoushan 316000, China [4]School of Life Sciences, Fudan University, Shanghai 200438, China
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关键词: Platelet Metastasis EMT CTC

摘要:
Platelets play a crucial role in cancer blood metastasis. Various cancer-related factors such as Toll-like receptors (TLRs), adenosine diphosphate (ADP) or extracellular matrix (ECM) can activate these small particles that function in hemostasis and thrombosis. Moreover, platelets induce Epithelial Mesenchymal Transition (EMT) to promote cancer progression and invasiveness. The activated platelets protect circulating tumor cells from immune surveillance and anoikis. They also mediate tumor cell arrest, extravasation and angiogenesis in distant organs through direct or indirect modulation, creating a metastatic microenvironment. This review summarizes the recent advances and progress of mechanisms in platelet activation and its interaction with cancer cells in metastasis.© 2023. BioMed Central Ltd., part of Springer Nature.

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出版当年[2022]版:
大类 | 4 区 医学
小类 | 4 区 医学:研究与实验
最新[2025]版:
大类 | 3 区 医学
小类 | 4 区 医学:研究与实验
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第一作者机构: [1]Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
通讯作者:
通讯机构: [3]Department of Oncology, Zhoushan Hospital of Traditional Chinese Medicine (Afliated to Zhejiang University of Traditional Chinese Medicine), Zhoushan 316000, China [4]School of Life Sciences, Fudan University, Shanghai 200438, China
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