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The regulation of tolerogenic dendritic cells by a Chinese herb formula improves abortion prone in mice

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机构： [1]Department of Traditional Chinese Medicine, Affiliated ShenzhenMaternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China [2]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China [3]Guangzhou University of Chinese Medicine, Guangzhou, China [4]Department of Respirology, Second Affiliated Hospital, HarbinMedical University, Harbin, China [5]Department of Pharmacy, Affiliated ShenzhenMaternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China [6]Guangdong Provincial Regional Disease Key Laboratory, Shenzhen, China [7]Institute of Allergy & Immunology of Shenzhen University, State Key Laboratory of Respiratory Disease Allergy Division at Shenzhen University, Shenzhen, China

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关键词： abortion prone decidua dendritic cell immune regulation pregnancy

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Abortion prone (AP) is a common clinical event. The underlying mechanism remains unclear. Traditional Chinese formulas are known to be efficient in the management of abortion. The purpose of this study is to observe the effects of Anzitiaochongtang (AZT), a traditional formulation of Chinese medicine, on improving AP in mice by regulating immune tolerance.An established abortion model (CBA/J×DBA/2) was employed. AZT was prepared and administered to mice in a manner consistent with clinical practice. Tolerogenic dendritic cells (tDC) and type 1 regulatory T cells (Tr1 cell) in mice were analyzed by immunological approaches to be used as representative immune tolerant parameters.An AP model was established with CBA/J × DBA/2 mice. The expression of IL-10 in tDC and Tr1 cell frequency in the mouse decidua tissues were lower in the AP group than that in the normal pregnancy (NP) group. Administration of AZT up regulated the expression of IL-10 in tDCs and Tr1 cell generation in the decidua tissues, and improved the pregnancy and tissue structure in AP mice. The main mechanism by which AZT improves pregnancy in AP mice is that AZT enhanced the expression of galectin-9 in the epithelial cells of decidua tissues. Galectin 9 activates TIM3 on DCs to promote the IL-10 expression. The DCs induced more Tr1 cells in the decidua tissues.Dysfunctional tDCs were detected in the AP decidua tissues. Administration of AZT improved pregnancy in AP mice by regulating tDC function and generation of Tr1 cells in the maternal-fetal interface.© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区生殖生物学 4 区免疫学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区免疫学 4 区生殖生物学

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第一作者机构： [1]Department of Traditional Chinese Medicine, Affiliated ShenzhenMaternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China

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通讯机构： [1]Department of Traditional Chinese Medicine, Affiliated ShenzhenMaternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China [6]Guangdong Provincial Regional Disease Key Laboratory, Shenzhen, China [7]Institute of Allergy & Immunology of Shenzhen University, State Key Laboratory of Respiratory Disease Allergy Division at Shenzhen University, Shenzhen, China [*1]Room A7-509, 1066 Xueyuan Blvd, Shenzhen 518055, China.

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