机构：[1]Department of Traditional Chinese Medicine, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong 510220, P.R. China.[2]Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong 510220, P.R. China.
Helicase POLQ‑like (HELQ or Hel308), is a highly conserved, 3'‑5' superfamily II DNA helicase that contributes to diverse DNA processes, including DNA repair, unwinding, and strand annealing. HELQ deficiency leads to subfertility, due to its critical role in germ cell stability. In addition, the abnormal expression of HELQ has been observed in multiple tumors and a number of molecular pathways, including the nucleotide excision repair, checkpoint kinase 1‑DNA repair protein RAD51 homolog 1 and ATM/ATR pathways, have been shown to be involved in HELQ. In the present review, the structure and characteristics of HELQ, as well as its major functions in DNA processing, were described. Molecular mechanisms involving HELQ in the context of tumorigenesis were also described. It was deduced that HELQ biology warrants investigation, and that its critical roles in the regulation of various DNA processes and participation in tumorigenesis are clinically relevant.
基金：
National Natural
Science Foundation of China (grant no. 81902802), the
National Science Foundation of Guangdong (grant no.2019A1515010633), the Guangzhou Science and Technology
Project (grant nos. 202102010060, 202102020766 and
202201010020), and the Guangzhou Science and Technology
Project of Traditional Chinese Medicine and Integrated
Traditional and Western Medicine (grant no. 20232A011007).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2025]版：
大类|3 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Traditional Chinese Medicine, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong 510220, P.R. China.
通讯作者：
通讯机构：[1]Department of Traditional Chinese Medicine, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong 510220, P.R. China.[2]Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong 510220, P.R. China.[*1]Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital of Jinan University, 396 Tongfu Zhong Road, Guangzhou, Guangdong 510220, P.R. China[*2]Department of Traditional Chinese Medicine, Guangzhou Red Cross Hospital of Jinan University, 396 Tongfu Zhong Road, Guangzhou, Guangdong 510220, P.R. China
推荐引用方式(GB/T 7714)：
Tang Nan,Wen Weilun,Liu Zhihe,et al.HELQ as a DNA helicase: Its novel role in normal cell function and tumorigenesis (Review)[J].Oncology reports.2023,50(6):doi:10.3892/or.2023.8657.
APA：
Tang Nan,Wen Weilun,Liu Zhihe,Xiong Xifeng&Wu Yanhua.(2023).HELQ as a DNA helicase: Its novel role in normal cell function and tumorigenesis (Review).Oncology reports,50,(6)
MLA：
Tang Nan,et al."HELQ as a DNA helicase: Its novel role in normal cell function and tumorigenesis (Review)".Oncology reports 50..6(2023)
