机构：[1]Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, China. [2]State Key Laboratory of Quality Research in Chinese Medicine & School of Pharmacy, Macau University of Science and Technology, Macau SAR 999078, China. [3]School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, 550000, China. [4]School of Pharmacy, Fujian Medical University, Fuzhou, 350000, China. [5]Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China. [6]Biomedical Science,Faculty of Life Sciences and Medicine,King's College London, Strand, London WC2R 2LS, England, United Kingdom.
Hydrogen sulfide (H2S) is a gasotransmitter with important physiological effects, including anti-inflammatory properties, regulation of oxidative stress, vasodilation, etc. Functional therapy involves using treatments that target the underlying cause of a disease, rather than simply treating symptoms. Epigenetics refer to changes in gene expression that occur through modifications to DNA, to the proteins that package DNA, or to non-coding RNA mechanisms. Recent research suggests that H2S may play a role in epigenetic regulation by altering DNA methylation patterns and regulating histone deacetylases, enzymes that modify histone proteins, or modulating miRNA mechanisms. These findings suggest that H2S may be a promising molecule for functional therapy in various diseases where epigenetic modifications are dysregulated.
基金：
This work was funded by the Macau Science and Technology Development fund (FDCT
(0021/2020/AGJ, 0011/2020/A1, 0012/2021/AMJ, 003/2022/ALC, 0092/2022/A2)); the
National Natural Science Foundation of China (Nos. 81973320). University Joint
Laboratory of Guangdong Province and Macao Region on Molecular Targets and
Intervention of Cardiovascular Diseases, Key platform of Department of Education of
Guangdong Province (2021LSYS007); the funding of Innovative research team of high-level
local universities in Shanghai and a key laboratory program of the Education Commission
of Shanghai Municipality (ZDSYS14005).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|2 区生物学
小类|2 区内分泌学与代谢2 区生化与分子生物学
最新[2025]版：
大类|2 区生物学
小类|2 区生化与分子生物学2 区内分泌学与代谢
第一作者：
第一作者机构：[1]Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, China. [2]State Key Laboratory of Quality Research in Chinese Medicine & School of Pharmacy, Macau University of Science and Technology, Macau SAR 999078, China. [3]School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, 550000, China.
共同第一作者：
通讯作者：
通讯机构：[2]State Key Laboratory of Quality Research in Chinese Medicine & School of Pharmacy, Macau University of Science and Technology, Macau SAR 999078, China. [5]Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.
推荐引用方式(GB/T 7714)：
Ding Qian,Song Wu,Zhu Menglin,et al.Hydrogen sulfide and functional therapy: novel mechanisms from epigenetics[J].Antioxidants & redox signaling.2023,doi:10.1089/ars.2023.0425.
APA：
Ding Qian,Song Wu,Zhu Menglin,Yu Yue,Lin Zhongxiao...&Zhu Yizhun.(2023).Hydrogen sulfide and functional therapy: novel mechanisms from epigenetics.Antioxidants & redox signaling,,
MLA：
Ding Qian,et al."Hydrogen sulfide and functional therapy: novel mechanisms from epigenetics".Antioxidants & redox signaling .(2023)
生物学