N-(E)-p-Coumaroyl tyrosine is a phenolic amino acid derivative extracted from the Abrus mollis Hance, Syn of Abrus melanospermus subsp. melanospermus, Fabaceae, which has anti-inflammatory activity. In this study, we aimed to investigate the inflammatory activity and mechanism of N-(E)-p-coumaroyl tyrosine by establishing a lipopolysaccharide-stimulated RAW 264.7 cells in vitro and an injured zebrafish tail fin in vivo. The results showed that N-(E)-p-coumaroyl tyrosine decreased the levels of ROS, NO, IL-6, IL-1 beta, and IL-18 secreted by LPS-induced RAW 264.7 macrophages. In addition, the results of in vivo studies showed that it inhibited the aggregation of neutrophils and macrophages to the tail after tail cutting stimulation. In summary, N-(E)-p-coumaroyl tyrosine inhibited the production of NO and ROS; decreased the secretions of IL-6, IL-1 beta, and IL-18; and reduced the aggregation of zebrafish neutrophils and macrophages. Therefore, N-(E)-p-coumaroyl tyrosine may be developed as a potential therapeutic option for inflammatory diseases.
基金：
This study was supported by the joint project of the
Department of Science and Technology of Guangdong Province
and the Guangdong Provincial Academy of Chinese Medical
Sciences (2016A020226038), Medical Science and Technology
Foundation of Guangdong Province (A2023220), and the
National Natural Science Foundation of China (81273780,
82174405).
第一作者机构：[1]Guangdong Pharmaceut Univ, Guangdong Prov Key Lab Adv Drug Delivery Syst, Guangzhou, Peoples R China[2]Guangdong Pharmaceut Univ, Ctr Drug Res & Dev, Guangzhou, Peoples R China[3]Guangdong Pharmaceut Univ, Guangdong Engn & Technol Res Ctr Top Precise Drug, Guangzhou, Peoples R China[4]Guangdong Prov Hosp Occupat Dis Prevent & Treatmen, Guangzhou, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Guangdong Pharmaceut Univ, Guangdong Prov Key Lab Adv Drug Delivery Syst, Guangzhou, Peoples R China[2]Guangdong Pharmaceut Univ, Ctr Drug Res & Dev, Guangzhou, Peoples R China[3]Guangdong Pharmaceut Univ, Guangdong Engn & Technol Res Ctr Top Precise Drug, Guangzhou, Peoples R China
推荐引用方式(GB/T 7714)：
Chen Lishi,Guo Yuhai,Yu Jiaxian,et al.Study on the Anti-inflammatory Activity of N-(E)-p-Coumaroyl Tyrosine In Vitro and In Vivo[J].REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY.2023,doi:10.1007/s43450-023-00500-9.
APA：
Chen, Lishi,Guo, Yuhai,Yu, Jiaxian,Liu, Roujia,Tang, Wenjing...&Yu, Chuqin.(2023).Study on the Anti-inflammatory Activity of N-(E)-p-Coumaroyl Tyrosine In Vitro and In Vivo.REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY,,
MLA：
Chen, Lishi,et al."Study on the Anti-inflammatory Activity of N-(E)-p-Coumaroyl Tyrosine In Vitro and In Vivo".REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY .(2023)
