机构：[1]Southwest Med Univ, Sch Basic Med Sci, Dept Physiol, Luzhou 646000, Peoples R China[2]Dongguan Huangjiang Hosp, Dept Gen Surg, Dongguan 523061, Guangdong, Peoples R China[3]Southwest Med Univ, Dept Orthoped, Affiliated Tradit Chinese Med Hosp, Luzhou 646000, Peoples R China[4]Shenzhen Second Peoples Hosp, Dept Bone Joint & Bone Oncol, Shenzhen 518035, Guangdong, Peoples R China[5]Shenzhen Second Peoples Hosp, Cent Lab, Shenzhen 518035, Guangdong, Peoples R China
AMP-activated protein kinase (AMPK) is a ubiquitous sensor of energy and nutritional status in eukaryotic cells. It plays a key role in regulating cellular energy homeostasis and multiple aspects of cell metabolism. During macrophage polarisation, AMPK not only guides the metabolic programming of macrophages, but also counter-regulates the inflammatory function of macrophages and promotes their polarisation toward the anti-inflammatory phenotype. AMPK is located at the intersection of macrophage metabolism and inflammation. The metabolic characteristics of macrophages are closely related to immune-related diseases, infectious diseases, cancer progression and immunotherapy. This review discusses the structure of AMPK and its role in the metabolism, function and polarisation of macrophages. In addition, it summarises the important role of the AMPK pathway and AMPK activators in the development of macrophage-related diseases.
基金：
Sichuan Science and Technology Program [2022NSFSC1368, 2022YFS0609]; Luzhou Science and Technology Program [2021-JYJ-71]; Scientific Research Foundation of Southwest Medical University [2021ZKMS009, 2021ZKQN012]; Shenzhen Science and Technology Projects [JCYJ20210324103604013]
第一作者机构：[1]Southwest Med Univ, Sch Basic Med Sci, Dept Physiol, Luzhou 646000, Peoples R China[2]Dongguan Huangjiang Hosp, Dept Gen Surg, Dongguan 523061, Guangdong, Peoples R China
通讯作者：
通讯机构：[4]Shenzhen Second Peoples Hosp, Dept Bone Joint & Bone Oncol, Shenzhen 518035, Guangdong, Peoples R China[5]Shenzhen Second Peoples Hosp, Cent Lab, Shenzhen 518035, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
Cui Yinxing,Chen Junhua,Zhang Zhao,et al.The role of AMPK in macrophage metabolism, function and polarisation[J].JOURNAL OF TRANSLATIONAL MEDICINE.2023,21(1):doi:10.1186/s12967-023-04772-6.
APA：
Cui, Yinxing,Chen, Junhua,Zhang, Zhao,Shi, Houyin,Sun, Weichao&Yi, Qian.(2023).The role of AMPK in macrophage metabolism, function and polarisation.JOURNAL OF TRANSLATIONAL MEDICINE,21,(1)
MLA：
Cui, Yinxing,et al."The role of AMPK in macrophage metabolism, function and polarisation".JOURNAL OF TRANSLATIONAL MEDICINE 21..1(2023)
医学