详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

Trim21 Regulates the Postnatal Development and Thermogenesis of Brown Adipose Tissue

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education of Jinan University, Guangzhou, Guangdong, 510630, China. [2]Department of Orthopedics, the Second Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, 233002, China. [3]Department of Joint and Sports Medicine, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, 526000, China. [4]The Research Center of Basic Integrative Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. [5]Department of Orthopedics, the Affiliated Shunde Hospital of Jinan University, Shunde, Guangdong, 528300, China.

出处：

DOI：

关键词： adipose tissue browning postnatal development thermogenesis Trim21

摘要：

Brown adipose tissue undergoes rapid postnatal development to mature and plays a crucial role in thermoregulation and energy expenditure, which protects against cold and obesity. Herein, it is shown that the expression of Trim21 mRNA level of interscapular brown adipose tissue elevates after birth, and peaks at P14 (postnatal day 14). Trim21 depletion severely impairs the maturation of interscapular brown adipose tissue, decreases the expression of a series of thermogenic genes, and reduces energy expenditure. Consistently, the loss of Trim21 also leads to a suppression of white adipose tissue "browning", in response to cold exposure and a β-adrenergic agonist, CL316,243. In addition, Trim21-/- mice are more prone to high-fat diet-induced obesity compared with the control littermates. Taken together, the study for the first time reveals a critical role of Trim21 in regulating iBAT postnatal development and thermogenesis.© 2023 Wiley-VCH GmbH.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 3 区生物学

小类 | 4 区材料科学：生物材料

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区材料科学：生物材料

第一作者：

第一作者机构： [1]Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education of Jinan University, Guangzhou, Guangdong, 510630, China.

共同第一作者：

通讯作者：

通讯机构： [1]Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education of Jinan University, Guangzhou, Guangdong, 510630, China. [5]Department of Orthopedics, the Affiliated Shunde Hospital of Jinan University, Shunde, Guangdong, 528300, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Phlorizin treatment attenuates obesity and related disorders through improving BAT thermogenesis [2]Transcriptomic Profile of the Mouse Postnatal Liver Development by Single-Nucleus RNA Sequencing. [3]Adipocyte-specific deletion of PIP5K1c reduces diet-induced obesity and insulin resistance by increasing energy expenditure. [4]Detection of brown adipose tissue in rats with acute cold stimulation using quantitative susceptibility mapping [5]Identification and analysis of key genes in adipose tissue for human obesity based on bioinformatics [6]Lipid parameters, adipose tissue distribution and prognosis prediction in chronic kidney Disease patients [7]Single-cell transcriptomics reveals zinc and copper ions homeostasis in epicardial adipose tissue of heart failure [8]Adipose tissue-derived stem cells inhibit hypertrophic scar (HS) fibrosis via p38/MAPK pathway. [9]穴位埋线治疗肥胖作用机制探讨 [10]Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis.