机构：[1]School of Chinese Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China[2]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, Guangdong, China广东省中医院[3]Department of Hepatobiliary Surgery, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China中山大学附属第三医院
Phlorizin is a member of the chalcone class of organic compounds and was originally extracted from apples. Intensive studies about phlorizin have been conducted. The aim of this study was to determine the therapeutic effects of phlorizin on diet-induced obese mice and to investigate the underlying mechanism. The results show that phlorizin has a beneficial impact on body weight and fat mass, alleviates lipid metabolism and glucose homeostasis. Brown adipose tissue (BAT) temperature was increased and morphological abnormalities were improved in obese mice after phlorizin treatment. Phlorizin activates the Tyk2/STAT3 signalling pathway, up-regulates the protein expression of UCP1, PPAR alpha, PPAR gamma, C/EBP beta and PRDM16, as well as increases BAT activity which contributes to antiobesity effects. This study suggests that phlorizin activates the Tyk2/STAT3 signalling pathway to induce thermogenesis in BAT and phlorizin has the therapeutic potential in treating obesity and comorbidity. (C) 2016 Elsevier Ltd. All rights reserved.
基金：
Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81303281]; Guangdong Province Outstanding Young Teachers Training Program [A1-AFD015141Z0203]; Central Finance of China in Support of the Development of Local Colleges and University [276]; Outstanding Youth Project of GZUCM [QNJJ201305]; [2015A030313044]
第一作者机构：[1]School of Chinese Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
共同第一作者：
通讯作者：
通讯机构：[1]School of Chinese Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China[3]Department of Hepatobiliary Surgery, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China[*1]Department of Hepatobiliary Surgery,The Third Affiliated Hospital of Sun Yat-Sen University,Tianhe District, Guangzhou Tianhe Road 600, Guangzhou, Guangdong, China 510000.[*2]School of Chinese Pharmaceutical Science, Guangzhou University of Chinese Medicine, University Town, Guangzhou, Guangdong, China 510006
推荐引用方式(GB/T 7714)：
Yuan Xin,Wu Yayun,Liang Jian,et al.Phlorizin treatment attenuates obesity and related disorders through improving BAT thermogenesis[J].JOURNAL OF FUNCTIONAL FOODS.2016,27:429-438.doi:10.1016/j.jff.2016.09.022.
APA：
Yuan, Xin,Wu, Yayun,Liang, Jian,Yuan, Huiqi,Zhao, Xuejie...&Hou, Shaozhen.(2016).Phlorizin treatment attenuates obesity and related disorders through improving BAT thermogenesis.JOURNAL OF FUNCTIONAL FOODS,27,
MLA：
Yuan, Xin,et al."Phlorizin treatment attenuates obesity and related disorders through improving BAT thermogenesis".JOURNAL OF FUNCTIONAL FOODS 27.(2016):429-438
