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Undescribed matrine-type alkaloids from Sophora alopecuroides with anti-inflammatory activity

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资源类型：
Pubmed体系：
作者：
Luo Ding[1,2,3] * ; Zou Jia-Wen[2] * ; Wang Jing-Hao[1] * ; Tian He[1] * ; Xie Hua-Yan[1] ; Zhu Tian-Xi[2] ; Zhu Hui-Hui[2] ; Deng Lu-Ming[4] ; Fan Chun-Lin[2] ; Wang Hao[1] ; Wang Guo-Cai[2] ; Zhang Yu-Bo[2,3,*1] ;
机构： [1]Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou, 510000, PR China [2]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China [3]State Key Laboratory of Bioactive Molecules and Druggability Assessment, and Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, 510632, PR China [4]Marine Biomedical Research Institution, Guangdong Medical University, Zhanjiang, 524023, PR China
出处：
DOI： 10.1016/j.phytochem.2023.113954
ISSN：

关键词： Sophora alopecuroides L Fabaceae Matrine-type alkaloids Sophaloseedlines I¡T Al(III) complex X-ray diffraction Anti-inflammatory

摘要：
A phytochemical investigation on the alkaloid fractions of Sophora alopecuroides L. led to the production of 11 undescribed matrine-type alkaloids, sophaloseedlines I-S (1-11), 12 known analogs (12-23), and an unexpected artificial matrine-derived Al(III) complex (24). The corresponding structures were elucidated by the interpretation of spectroscopic analyses, quantum chemical calculation, and six instances (1-4, 18, and 24), verified by X-ray crystallography. The biological activities screening demonstrated that none of the isolates exhibited cytotoxicity against four human cancer cell lines (HepG2, A549, THP-1, and MCF-7) and respiratory syncytial virus (RSV) at 50 μM, while moderate anti-inflammatory activity with IC50 value from 15.6 to 47.8 μM was observed. The key structure-activity relationships of those matrine-type alkaloids for anti-inflammatory effects have been summarized. In addition, the most potent 7-epi-sophoramine (19) and aluminum sophaloseedline T (24) could effectively inhibit the release of pro-inflammatory factors (TNF-α, IL-6, and IL-1β), as well as the expression of iNOS and COX-2 proteins.Copyright © 2023. Published by Elsevier Ltd.

基金：
This work was financially supported by the National Natural Science Foundation of China (nos. 82273803, 82304320, 82074116, 82071340), the Guangdong Basic and Applied Basic Research Foundation (no. 2020B1515020033), the Fundamental Research Funds for the Central Universities (no. 21623224), we also thank the Analytical and Testing Center of Jinan University, and the High Performance Public Computing Service Platform of Jinan University.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 生物学
小类 | 2 区 植物科学 2 区 生化与分子生物学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 植物科学
第一作者：
第一作者机构： [1]Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou, 510000, PR China [2]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China [3]State Key Laboratory of Bioactive Molecules and Druggability Assessment, and Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, 510632, PR China
共同第一作者：
通讯作者：
通讯机构： [2]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China [3]State Key Laboratory of Bioactive Molecules and Druggability Assessment, and Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, 510632, PR China [*1]Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China.
推荐引用方式(GB/T 7714)：
Luo Ding,Zou Jia-Wen,Wang Jing-Hao,et al.Undescribed matrine-type alkaloids from Sophora alopecuroides with anti-inflammatory activity[J].Phytochemistry.2023,113954.doi:10.1016/j.phytochem.2023.113954.
APA：
Luo Ding,Zou Jia-Wen,Wang Jing-Hao,Tian He,Xie Hua-Yan...&Zhang Yu-Bo.(2023).Undescribed matrine-type alkaloids from Sophora alopecuroides with anti-inflammatory activity.Phytochemistry,,
MLA：
Luo Ding,et al."Undescribed matrine-type alkaloids from Sophora alopecuroides with anti-inflammatory activity".Phytochemistry .(2023):113954

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