Bacterial cellulose/oxidized bacterial cellulose nanofibrils (BC/oxBCNFs) macro-fibers are developed as a novel scaffold for vascular tissue engineering. Utilizing a low-speed rotary coagulation spinning technique and precise solvent control, macro-fibers with a unique heterogeneous structure with dense surface and porous core are created. Enhanced by a polydopamine (PDA) coating, these macro-fibers offer robust mechanical integrity, high biocompatibility, and excellent cell adhesion. When cultured with endothelial cells (ECs) and smooth muscle cells (SMCs), the macro-fibers support healthy cell proliferation and exhibit a unique spiral SMC alignment, demonstrating their vascular suitability. This innovative strategy opens new avenues for advances in tissue engineering. Utilizing a new preparation strategy, the combined application of rotary coagulation bath, and controlled solvent evaporation, a novel BC-based macro-fiber with a heterogeneous and ECM-like structure is successfully developed. This novel PDA@(BC/oxBCNFs) macro-fibers and their prepared method offer new opportunities for the development of advanced biomaterials in tissue engineering and regenerative medicine.image
基金:
National Natural Science Foundation of China
(Grant No. 22078197, 22378267, 52172283, 81900677), the Natural Science
Foundation of Guangdong Province (Grant No. 2021A1515012506),
Guangdong Basic and Applied Basic Research Foundation (Grant No.
2020A1515110480, 2022A1515110246, 2023A1515011827), Shenzhen Science
and Technology Program (Grant No. RCYX20221008092902010,
20220810120421001).
第一作者机构:[1]Shenzhen Univ, Sch Med, Dept Biomed Engn, Shenzhen 518000, Guangdong, Peoples R China
共同第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
Wu Nihuan,Meng Si,Li Zhen,et al.Tailoring the Heterogeneous Structure of Macro-Fibers Assembled by Bacterial Cellulose Nanofibrils for Tissue Engineering Scaffolds[J].SMALL.2024,doi:10.1002/smll.202307603.
APA:
Wu, Nihuan,Meng, Si,Li, Zhen,Fang, Jie,Qi, Cheng...&Liu, Zhou.(2024).Tailoring the Heterogeneous Structure of Macro-Fibers Assembled by Bacterial Cellulose Nanofibrils for Tissue Engineering Scaffolds.SMALL,,
MLA:
Wu, Nihuan,et al."Tailoring the Heterogeneous Structure of Macro-Fibers Assembled by Bacterial Cellulose Nanofibrils for Tissue Engineering Scaffolds".SMALL .(2024)