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Tailoring the Heterogeneous Structure of Macro-Fibers Assembled by Bacterial Cellulose Nanofibrils for Tissue Engineering Scaffolds

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机构: [1]Shenzhen Univ, Sch Med, Dept Biomed Engn, Shenzhen 518000, Guangdong, Peoples R China [2]Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen 518000, Guangdong, Peoples R China [3]Guangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Dept Gastroenterol, Clin Med Coll 4, Shenzhen 510006, Guangdong, Peoples R China [4]Shenzhen Univ, Coll Mechatron & Control Engn, Guangdong Prov Key Lab Micronano Optomechatron Eng, Shenzhen 518060, Guangdong, Peoples R China [5]Shenzhen Univ, Shenzhen Peoples Hosp 2, Shenzhen Inst Translat Med, Dept Urol,Affiliated Hosp 1, Shenzhen 518037, Guangdong, Peoples R China
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关键词: celluloses nanofibrils scaffolds surfaces tissue engineering

摘要:
Bacterial cellulose/oxidized bacterial cellulose nanofibrils (BC/oxBCNFs) macro-fibers are developed as a novel scaffold for vascular tissue engineering. Utilizing a low-speed rotary coagulation spinning technique and precise solvent control, macro-fibers with a unique heterogeneous structure with dense surface and porous core are created. Enhanced by a polydopamine (PDA) coating, these macro-fibers offer robust mechanical integrity, high biocompatibility, and excellent cell adhesion. When cultured with endothelial cells (ECs) and smooth muscle cells (SMCs), the macro-fibers support healthy cell proliferation and exhibit a unique spiral SMC alignment, demonstrating their vascular suitability. This innovative strategy opens new avenues for advances in tissue engineering. Utilizing a new preparation strategy, the combined application of rotary coagulation bath, and controlled solvent evaporation, a novel BC-based macro-fiber with a heterogeneous and ECM-like structure is successfully developed. This novel PDA@(BC/oxBCNFs) macro-fibers and their prepared method offer new opportunities for the development of advanced biomaterials in tissue engineering and regenerative medicine.image

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出版当年[2023]版:
大类 | 2 区 材料科学
小类 | 1 区 物理:应用 2 区 化学:综合 2 区 物理化学 2 区 材料科学:综合 2 区 纳米科技 2 区 物理:凝聚态物理
最新[2025]版:
大类 | 2 区 材料科学
小类 | 2 区 化学:综合 2 区 材料科学:综合 2 区 纳米科技 2 区 物理:应用 2 区 物理:凝聚态物理
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出版当年[2022]版:
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 CHEMISTRY, PHYSICAL Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY Q1 PHYSICS, APPLIED Q1 PHYSICS, CONDENSED MATTER
最新[2023]版:
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 CHEMISTRY, PHYSICAL Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY Q1 PHYSICS, APPLIED Q1 PHYSICS, CONDENSED MATTER

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第一作者机构: [1]Shenzhen Univ, Sch Med, Dept Biomed Engn, Shenzhen 518000, Guangdong, Peoples R China
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