个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Decoding active compounds and molecular targets of herbal medicine by high-throughput metabolomics technology: A systematic review

| 认领 | 导出 | |

文献详情

资源类型：
Pubmed体系：
作者：
Wang Zhibo[1,2] * ; Guo Sifan[1] ; Cai Ying[1,2] ; Yang Qiang[2] ; Wang Yan[1] ; Yu Xiaodan[1] ; Sun Wanying[1] ; Qiu Shi[1] ; Li Xiancai[3] ; Guo Yu[1] ; Xie Yiqiang[1] ; Zhang Aihua[1,2,*1] ; Zheng Shaojiang[4] ;
机构： [1]Scientific Experiment Center, Hainan General Hospital, International Advanced Functional Omics Platform, International Joint Research Center on Traditional Chinese and Modern Medicine, Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province, Hainan Engineering Research Center for Biological Sample Resources of Major Diseases, Hainan Medical University, Xueyuan Road 3, Haikou 571199, China [2]Graduate School, Heilongjiang University of Chinese Medicine, Harbin 150040, China [3]Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Guangzhou 510650, China [4]Medical Research Center of The First Affiliated Hospital, Hainan Women and Children Medical Center, Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Medical University, Haikou 571199, China
出处：
DOI： 10.1016/j.bioorg.2023.107090
ISSN：

关键词： Metabolomics Herbal medicine Bioactive compounds Molecular targets Efficacy evaluation

摘要：
Clinical experiences of herbal medicine (HM) have been used to treat a variety of human intractable diseases. As the treatment of diseases using HM is characterized by multi-components and multi-targets, it is difficult to determine the bio-active components, explore the molecular targets and reveal the mechanisms of action. Metabolomics is frequently used to characterize the effect of external disturbances on organisms because of its unique advantages on detecting changes in endogenous small-molecule metabolites. Its systematicity and integrity are consistent with the effective characteristics of HM. After HM intervention, metabolomics can accurately capture and describe the behavior of endogenous metabolites under the disturbance of functional compounds, which will be used to decode the bioactive ingredients of HM and expound the molecular targets. Metabolomics can provide an approach for explaining HM, addressing unclear clinical efficacy and undefined mechanisms of action. In this review, the metabolomics strategy and its applications in HM are systematically introduced, which offers valuable insights for metabolomics methods to characterizing the pharmacological effects and molecular targets of HM.Copyright © 2024 Elsevier Inc. All rights reserved.

基金：
The authors are grateful for the generous support from the Program of Natural Science Foundation of State (Grant No. 81973745, 82104733, 81302905), Talent Lift Engineering Project of China Association of TCM (QNRC2-B06), Natural Science Foundation of Heilongjiang Province (YQ2019H030), Hainan Province Science and Technology Special Fund (ZDYF2022SHFZ065), the Specific Research Fund of The Innovation Platform for Academicians of Hainan Province (YSPTZX202208), and Hainan Province Clinical Medical Center (QWYH2022341).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 1 区 有机化学 2 区 生化与分子生物学
最新[2025]版：
大类 | 2 区 医学
小类 | 1 区 有机化学 2 区 生化与分子生物学
第一作者：
第一作者机构： [1]Scientific Experiment Center, Hainan General Hospital, International Advanced Functional Omics Platform, International Joint Research Center on Traditional Chinese and Modern Medicine, Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province, Hainan Engineering Research Center for Biological Sample Resources of Major Diseases, Hainan Medical University, Xueyuan Road 3, Haikou 571199, China [2]Graduate School, Heilongjiang University of Chinese Medicine, Harbin 150040, China
通讯作者：
通讯机构： [1]Scientific Experiment Center, Hainan General Hospital, International Advanced Functional Omics Platform, International Joint Research Center on Traditional Chinese and Modern Medicine, Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province, Hainan Engineering Research Center for Biological Sample Resources of Major Diseases, Hainan Medical University, Xueyuan Road 3, Haikou 571199, China [2]Graduate School, Heilongjiang University of Chinese Medicine, Harbin 150040, China [*1]Scientific Experiment Center, Hainan General Hospital, International Advanced Functional Omics Platform, International Joint Research Center on Traditional Chinese and Modern Medicine, Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province, Hainan Medical University, Xueyuan Road 3, Haikou 571199, China
推荐引用方式(GB/T 7714)：
Wang Zhibo,Guo Sifan,Cai Ying,et al.Decoding active compounds and molecular targets of herbal medicine by high-throughput metabolomics technology: A systematic review[J].Bioorganic Chemistry.2024,144:107090.doi:10.1016/j.bioorg.2023.107090.
APA：
Wang Zhibo,Guo Sifan,Cai Ying,Yang Qiang,Wang Yan...&Zheng Shaojiang.(2024).Decoding active compounds and molecular targets of herbal medicine by high-throughput metabolomics technology: A systematic review.Bioorganic Chemistry,144,
MLA：
Wang Zhibo,et al."Decoding active compounds and molecular targets of herbal medicine by high-throughput metabolomics technology: A systematic review".Bioorganic Chemistry 144.(2024):107090

相关文献

[1]Efficacy evaluation, active ingredients, and multitarget exploration of herbal medicine [2]Chemical Variation of Chenpi (Citrus Peels) and Corresponding Correlated Bioactive Compounds by LC-MS Metabolomics and Multibioassay Analysis [3]灯盏花乙素的潜在作用靶标虚拟筛选 [4]Anti-colorectal cancer of Ardisia gigantifolia Stapf. and targets prediction via network pharmacology and molecular docking study [5]Clinical Evaluation of Herbal Medicine (ICH-012) in Treating Acute Cerebral Haemorrhage: Safety and Efficacy from 6-to 72-Hour Time Window (CRRICHTrial-II) [6]Potential anticancer activities of securinine and its molecular targets [7]大型双盲临床试验中药安慰剂制备方法及效果评价研究 [8]Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis. [9]Concurrent quantification and comparative pharmacokinetic analysis of bioactive compounds in the Herba Ephedrae-Semen Armeniacae Amarum herb pair. [10]Antiviral and Antioxidant Components from the Fruits of Illicium verum Hook.f. (Chinese Star Anise).

资源点击量：2018 今日访问量：0 总访问量：645 更新日期：2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持：重庆聚合科技有限公司 地址：广州市越秀区大德路111号