机构：[1]School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.[2]National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China.[3]Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830011, China.[4]Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.中山大学附属第六医院[5]Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.中山大学附属第六医院[6]Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, China.[7]Key Laboratory of Biomedical Engineering of Guangdong Province, and Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China.
Multifunctional dressing biomaterials that can promote tissue adhesion, hemostasis, and soft-tissue wound healing are of great clinical significance. Here, we report a nanocomposite supramolecular sponge constructed by an air-in-water emulsion template composed of methacrylated gelatin (GelMA), Laponite nanoclay, and branched supramolecular polymer (PAMU). The sponge has an interconnected macroporous structure and exhibits tunable mechanical properties with varying Laponite concentration. The nanoengineered sponge is endowed with tissue adhesion by intermolecular hydrogen bonds and ionic interactions contributed by the supramolecular polymer and the Laponite nanoclay. The biocompatible sponge facilitates cell proliferation and blood coagulation in both in vitro and in vivo experiments. In addition, the results of the rat external abdominal wall defect model show that the sponge can promote angiogenesis, collagen deposition, and granulation tissue formation to accelerate wound repair. These findings suggest that the unique air-in-water templated sponge is a promising candidate for applications in hemostasis and wound healing.
基金：
This work was financially supported by the National Key
Research and Development Program of China
(2022YFC2410104), Natural Science Foundation of Guangxi
( 2023GXNSFAA026140), National Natural Science Founda-
tion of China (22072047, 82101 10933), Guangdong Basic and
Applied Basic Research Foundation (2023A1515010977),
Xinjiang Autonomous Region Technology Plan
(2022E02125)，Medical Scientific Research Foundation of
Guangdong Province (A2023081 ), and Dongguan Science and
Technology of Social Development Program
(20211800904702, 20231800904303).
第一作者机构：[1]School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.[2]National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China.
共同第一作者：
通讯作者：
通讯机构：[1]School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.[2]National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China.[6]Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, China.[7]Key Laboratory of Biomedical Engineering of Guangdong Province, and Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China.
推荐引用方式(GB/T 7714)：
Zhang Runlin,Peng Jingqi,Wei Yingqi,et al.Nanoengineered Supramolecular Adhesive Sponge for Rapid Hemostasis and Abdominal Wall Wound Healing[J].ACS APPLIED BIO MATERIALS.2024,7(2):1290-1300.doi:10.1021/acsabm.3c01220.
APA：
Zhang Runlin,Peng Jingqi,Wei Yingqi,Sun Shuo,Xie Manshan...&Chen Yunhua.(2024).Nanoengineered Supramolecular Adhesive Sponge for Rapid Hemostasis and Abdominal Wall Wound Healing.ACS APPLIED BIO MATERIALS,7,(2)
MLA：
Zhang Runlin,et al."Nanoengineered Supramolecular Adhesive Sponge for Rapid Hemostasis and Abdominal Wall Wound Healing".ACS APPLIED BIO MATERIALS 7..2(2024):1290-1300
