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Satellite Cell-Derived Exosomes: A Novel Approach to Alleviate Skeletal Muscle Atrophy and Fibrosis

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资源类型：
Pubmed体系：
作者：
Liu Hongwen[1,2] * ; Yuan Shiguo[3,4] * ; Liu Gaofeng[1] ; Li Junhua[1] ; Zheng Kai[3,4] ; Zhang Zhiwei[3,4] ; Zheng Sheng[5] ; Yin Li[2] ; Li Yikai[5] ;
机构： [1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China. [2]Department of Discipline Construction Office, Panzhihua Central Hospital, Panzhihua, Sichuan, 617067, China. [3]Department of Orthopaedic, Hainan Traditional Chinese Medicine Hospital, Haikou, Hainan, 570203, China. [4]School of Chinese Medicine, Hainan Medical University, Haikou, Hainan, 571199, China. [5]Department of Traditional Chinese Orthopedics and Traumatology, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, 510630, China.
出处：
DOI： 10.1002/adbi.202300558

关键词： exosomes muscle atrophy muscle fibrosis satellite cells

摘要：
Skeletal muscle atrophy coincides with extensive fibrous tissue hyperplasia in muscle-atrophied patients, and fibrous tissue plays a vital role in skeletal muscle function and hinders muscle fiber regeneration. However, effective drugs to manage skeletal muscle atrophy and fibrosis remain elusive. This study isolated and characterized exosomes derived from skeletal muscle satellite cells (MuSC-Exo). The study investigated their effects on denervated skeletal muscle atrophy and fibrosis in Sprague Dawley (SD) rats via intramuscular injection. MuSC-Exo demonstrated the potential to alleviate skeletal muscle atrophy and fibrosis. The underlying mechanism using single-cell RNA sequencing data and functional analysis are analyzed. Mechanistic studies reveal close associations between fibroblasts and myoblasts, with the transforming growth factor β1 (TGF-β1)-Smad3-Pax7 axis governing fibroblast activation in atrophic skeletal muscle. MuSC-Exo intervention inhibited the TGF-β1/Smad3 pathway and improved muscle atrophy and fibrosis. In conclusion, MuSC-Exo-based therapy may represent a novel strategy to alleviate skeletal muscle atrophy and reduce excessive fibrotic tissue by targeting Pax7 through the TGF-β1/Smad3 pathway.© 2024 Wiley-VCH GmbH.

基金：
This study was supported by the Sanming Project of Medicine in Shenzhen (No. SZZYSM202108013), the President Foundation of The Third Affiliated Hospital of Southern Medical University (No. YP202210), the Natural Science Foundation of Hainan Province (grant No. 822MS183), the Hainan Province Clinical Medical Center ([2021] No. 276), and the National Natural Science Foundation of China (No. 82 274 669)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 生物学
小类 | 4 区 材料科学：生物材料
最新[2025]版：
大类 | 4 区 生物学
小类 | 4 区 材料科学：生物材料
第一作者：
第一作者机构： [1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China. [2]Department of Discipline Construction Office, Panzhihua Central Hospital, Panzhihua, Sichuan, 617067, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Hongwen,Yuan Shiguo,Liu Gaofeng,et al.Satellite Cell-Derived Exosomes: A Novel Approach to Alleviate Skeletal Muscle Atrophy and Fibrosis[J].Advanced Biology.2024,e2300558.doi:10.1002/adbi.202300558.
APA：
Liu Hongwen,Yuan Shiguo,Liu Gaofeng,Li Junhua,Zheng Kai...&Li Yikai.(2024).Satellite Cell-Derived Exosomes: A Novel Approach to Alleviate Skeletal Muscle Atrophy and Fibrosis.Advanced Biology,,
MLA：
Liu Hongwen,et al."Satellite Cell-Derived Exosomes: A Novel Approach to Alleviate Skeletal Muscle Atrophy and Fibrosis".Advanced Biology .(2024):e2300558

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