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Xiao-qing-long-tang ameliorates OVA-induced allergic rhinitis by inhibiting ILC2s through the IL-33/ST2 and JAK/STAT pathways

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资源类型：
Pubmed体系：
作者：
Zhang Jia-Jun[1,3] * ; He Xue-Cheng[1] * ; Zhou Min[2] ; Liu Qin-Dong[1] ; Xu Wei-Zhen[1] ; Yan Ya-Jie[2,4,*1] ; Ruan Yan[2,4,*1] ;
机构： [1]The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China [2]Otorhinolaryngology Department, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China [3]Department of Otorhinolaryngology, the Second People’s Hospital of Foshan, Affiliated Foshan Hospital of Southern Medical University, Foshan, Guangdong Province, 528099, China [4]Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, 510405, China
出处：
DOI： 10.1016/j.phymed.2023.155012
ISSN：

关键词： Xiao-qing-long-tang Allergic rhinitis ILC2s IL-33/ST2 signaling JAK/STAT pathway

摘要：
Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa that is mediated by immunoglobulin E (IgE). Xiao-qing-long-tang (XQLT) is a traditional Chinese medicine compound that is widely used to treat respiratory diseases such as AR. However, the underlying mechanism of the effect of XQLT on AR remains unclear.To elucidate the effect of XQLT on ovalbumin (OVA)-induced AR and the mechanisms of action.The therapeutic efficacy of XQLT was evaluated in a well-established OVA-induced AR mouse model. Nasal symptoms were analyzed, type 2 cytokines and OVA-sIgE levels were measured, nasal mucosa tissues were collected for histological analysis, and the changes of Group 2 innate lymphoid cells (ILC2s) and the IL-33/ST2 and JAK/STAT signaling pathways in the nasal mucosa were observed.XQLT significantly alleviated the nasal symptoms and histological damage to the nasal mucosa in AR mice, and reduced the levels of type 2 cytokines and OVA-sIgE. In addition, after XQLT treatment, the numbers of ILC2s in the nasal mucosa of AR mice were reduced, and the mRNA levels of the transcription factors GATA3 and ROR-α were decreased. Moreover, IL-33/ST2 signaling pathway was inhibited. The costimulatory cytokine associated JAK/STAT signaling pathway was also inhibited in ILC2s.Our study demonstrated that XQLT regulated ILC2s through the IL-33/ST2 and JAK/STAT pathways to ameliorate type 2 inflammation in OVA-induced AR. These findings suggest that XQLT might be used to treat AR.Copyright © 2023. Published by Elsevier GmbH.

基金：
This research was funded by a grant from the National Natural Science Foundation of China (no. 81974581, 82274590), Basic and Applied Research Foundation of Guangdong Province, China (no. 2021A1515110446), and Science and Technology Basic and Applied Basic Research Project of Guangzhou (no. 202201011211). This study was supported by the Lingnan Medical Research Center of Guangzhou University of Chinese Medicine. In addition, we would like to thank Man-qing Lin, Teng-yu Chen, Dan Li and Cai-shan Fang for their helps in the experiment
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 药物化学 1 区 药学 1 区 全科医学与补充医学 1 区 植物科学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 药物化学 1 区 全科医学与补充医学 1 区 药学 1 区 植物科学
第一作者：
第一作者机构： [1]The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China [3]Department of Otorhinolaryngology, the Second People’s Hospital of Foshan, Affiliated Foshan Hospital of Southern Medical University, Foshan, Guangdong Province, 528099, China
共同第一作者：
通讯作者：
通讯机构： [2]Otorhinolaryngology Department, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China [4]Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, 510405, China [*1]Otorhinolaryngology Department, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, 16 Jichang Road, Baiyun District, Guangzhou, Guangdong Province, 510405, China.
推荐引用方式(GB/T 7714)：
Zhang Jia-Jun,He Xue-Cheng,Zhou Min,et al.Xiao-qing-long-tang ameliorates OVA-induced allergic rhinitis by inhibiting ILC2s through the IL-33/ST2 and JAK/STAT pathways[J].Phytomedicine : international journal of phytotherapy and phytopharmacology.2023,119:155012.doi:10.1016/j.phymed.2023.155012.
APA：
Zhang Jia-Jun,He Xue-Cheng,Zhou Min,Liu Qin-Dong,Xu Wei-Zhen...&Ruan Yan.(2023).Xiao-qing-long-tang ameliorates OVA-induced allergic rhinitis by inhibiting ILC2s through the IL-33/ST2 and JAK/STAT pathways.Phytomedicine : international journal of phytotherapy and phytopharmacology,119,
MLA：
Zhang Jia-Jun,et al."Xiao-qing-long-tang ameliorates OVA-induced allergic rhinitis by inhibiting ILC2s through the IL-33/ST2 and JAK/STAT pathways".Phytomedicine : international journal of phytotherapy and phytopharmacology 119.(2023):155012

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