机构：[1]Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Jiangsu, China江苏省人民医院[2]The Second Clinical Medical School, Nanjing University of Chinese Medicine, Jiangsu, China[3]The Teaching and Research Department of Statistics, Nanjing Medical University, Jiangsu, China[4]Rehabilitation Center, The Second Affiliated Hospital of HaiNan Medical University, Hainan, China[5]The Rehabilitation Department, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Henan, China[6]The Acupuncture Rehabilitation Department, Jiangsu Province Hospital of Traditional Chinese Medicine, Jiangsu, China江苏省人民医院[7]Rehabilitation Center, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang, China[8]The Rehabilitation Department, Guangdong Provincial Traditional Chinese Medicine Hospital, Guangdong, China广东省中医院[9]The Rehabilitation Department, Tongji Medical College Huazhong University of Science & Technology, Hubei, China[10]The Neurological Rehabilitation Department, Shanghai University of Traditional Chinese Medicine, Shanghai, China[11]Rehabilitation Center, Xuzhou Central Hospital, Jiangsu, China[12]The Rehabilitation Department, The Affiliated Hospital of Xuzhou Medical University, Jiangsu, China[13]The Rehabilitation Department, Tianjin Medical University General Hospital, Tianjin, China[14]The Neurology Department, Nanjing Hospital of Traditional Chinese Medicine, Jiangsu, China[15]The Rehabilitation Department, Hubei Provincial Hospital of Integrated Chinese & Western Medicine, Hubei, China[16]The Rehabilitation Department, Dongguan Kanghua Hospital, Guangdong, China[17]School of Basic Medical Sciences, Nanjing Medical University, Jiangsu, China
Objective: To determine the short- (4 weeks) and long-term (6 month) effectiveness of Tibetan medicated bathing therapy in patients with post-stroke limb spasticity. Design: Prospective, blinded, randomized controlled trial. Subjects: Post-stroke patients with limb spasticity were recruited between December 2013 and February 2017 and randomly assigned 1:1 to a control group that received conventional rehabilitation (n = 222) or an experimental group that received Tibetan medicated bathing therapy in combination with conventional rehabilitation (n = 222). Methods: All patients received conventional rehabilitation. In addition, the experimental group received Tibetan medicated bathing therapy. The interventions were conducted 5 times per week for 4 weeks. The primary endpoint was changes from baseline after 4 weeks of therapy in muscle tone in the spastic muscles (elbow flexors, wrist flexors, finger flexors, knee extensors, ankle plantar flexors), as measured by the Modified Ashworth Scale (MAS). Results: The mean change from baseline after 4 weeks of therapy in the MAS score for the elbow flexors (P =.017), wrist flexors (P<.001), and ankle plantar flexors (P<.001) was significantly greater in patients in the experimental group compared to the control group. The benefit was maintained for 3 muscle groups (elbow flexors P <.001, wrist flexors P =.001, and ankle plantar flexors P <.001) and 6 months (elbow flexors P <.001, wrist flexors P = .002, and ankle plantar flexors P <.001) after therapy. All adverse events were mild, and no serious adverse reactions to Tibetan medicated bathing therapy were recorded. Conclusions and Implications: Tibetan medicated bathing therapy, in combination with conventional rehabilitation, has potential as a safe, effective treatment for the alleviation of post-stroke upper limb spasticity. Tibetan medicated bathing therapy was most advantageous for patients who had a baseline muscle tone score of 1+ to 2 on the MAS in the affected limb and recent onset of stroke (duration of the disease of 1-3 months). (C) 2019 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
基金：
Ministry of Science and Technology of the People's Republic of China through the Twelfth Five-Year National Science and Technology Pillar Program [2013BAI10B04]
第一作者机构：[1]Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Jiangsu, China[2]The Second Clinical Medical School, Nanjing University of Chinese Medicine, Jiangsu, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Jiangsu, China[17]School of Basic Medical Sciences, Nanjing Medical University, Jiangsu, China[*1]The Department of Physical and Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, Jiangsu 210029, P.R. China.[*2]School of Basic Medical Sciences, Nanjing Medical University, No.101 Longmian Road, Nanjing, Jiangsu 211166, P.R. China
推荐引用方式(GB/T 7714)：
Wang Meng,Liu Shouguo,Peng Zhihang,et al.Tibetan Medicated Bathing Therapy for Patients With Post-stroke Limb Spasticity: A Randomized Controlled Clinical Trial[J].JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION.2020,21(3):374-+.doi:10.1016/j.jamda.2019.10.018.
APA：
Wang, Meng,Liu, Shouguo,Peng, Zhihang,Zhu, Yi,Feng, Xiaodong...&Li, Jianan.(2020).Tibetan Medicated Bathing Therapy for Patients With Post-stroke Limb Spasticity: A Randomized Controlled Clinical Trial.JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION,21,(3)
MLA：
Wang, Meng,et al."Tibetan Medicated Bathing Therapy for Patients With Post-stroke Limb Spasticity: A Randomized Controlled Clinical Trial".JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION 21..3(2020):374-+
医学