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Saniculamin C, a new flavonoid from Sanicula lamelligera

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机构: [1]General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, China [2]Traditional Chinese Medicine Hospital of Guangdong Province, Guangzhou 510120, China [3]The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China
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关键词: Sanicula lamelligera Apiaceae flavonoid cytotoxicity

摘要:
A new flavonoid named saniculamin C (1), together with six known compounds (2-7), were isolated from the whole plants of Sanicula lamelligera Hance. The chemical structures were elucidated by spectroscopic and physico-chemical analyses. All isolates were evaluated for in vitro cytotoxic activities against four human cancer cell lines, HepG2, SGC-7901 gastric cancer, Hela and A-549 lung cancer. Compound 1 showed potent antiproliferative activities against SGC-7901 cells with IC50 value of 7.45 mu M. In addition, compound 6 exhibited weak antiproliferative activities against HepG2, SGC-7901, Hela cancer cells with IC50 values of 10.43, 8.24 and 15.32 mu M, respectively.

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出版当年[2020]版:
大类 | 4 区 医学
小类 | 4 区 应用化学 4 区 药物化学 4 区 药学 4 区 植物科学
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 应用化学 4 区 药物化学 4 区 药学 4 区 植物科学
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出版当年[2019]版:
Q3 PLANT SCIENCES Q3 CHEMISTRY, APPLIED Q4 CHEMISTRY, MEDICINAL Q4 PHARMACOLOGY & PHARMACY
最新[2023]版:
Q3 CHEMISTRY, APPLIED Q3 PLANT SCIENCES Q4 CHEMISTRY, MEDICINAL Q4 PHARMACOLOGY & PHARMACY

影响因子: 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

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第一作者机构: [1]General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, China [*1]General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, China
通讯作者:
通讯机构: [1]General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, China [3]The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China [*1]General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, China [*2]General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, China
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