机构：[1]Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China[2]Guangdong South China United Vaccine Institute, Guangzhou, China[3]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China广东省中医院[4]Department of Pharmacy, School of Medicine, Shenzhen University, 3688 Nanhai Boulevard, Nanshan District, Shenzhen, Guangdong, China深圳市康宁医院深圳医学信息中心[5]Institute of Traditional Chinese Medicine and Natural Products and Guangdong Province, Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, China[6]School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, China[7]The First Affiliated Hospital, Guangdong Pharmaceutical University, Guangzhou, China[8]Sino-French Hoffmann Institute of Immunology, College of Basic Medical Science, Guangzhou Medical University, Guangzhou, China
Early events in herpes simplex virus type 1 (HSV-1) infection reactivate latent human immunodeficiency virus, Epstein Barr virus, and human papillomavirus in the presence of acyclovir (ACV). The common use of nucleoside analog medications, such as ACV and pencyclovir, has resulted in the emergence of drug resistant HSV-1 strains in clinical therapy. Therefore, new antiherpetics that can inhibit early events in HSV-1 infection should be developed. An example of this treatment is Houttuynia cordata Thunb. water extract, which can inhibit HSV-1 infection through multiple mechanisms. In this study, the anti-HSV-1 activity of Houttuynoid A, a new type of flavonoid isolated from H. cordata, was investigated. Three different assays confirmed that this compound could exhibit strong in vitro anti-HSV-1 activity. One assay verified that this compound could inhibit HSV-1 multiplication and prevent lesion formation in a HSV-1 infection mouse model. Mechanism analysis revealed that this compound could inactivate HSV-1 infectivity by blocking viral membrane fusion. Moreover, Houttuynoid A exhibited antiviral activities against other alpha herpes viruses, such as HSV-2 and varicella zoster virus (VZV). In conclusion, Houttuynoid A may be a useful antiviral agent for HSV-1. (C) 2017 Elsevier B.V. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31370204]
第一作者机构：[1]Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
通讯作者：
通讯机构：[2]Guangdong South China United Vaccine Institute, Guangzhou, China[8]Sino-French Hoffmann Institute of Immunology, College of Basic Medical Science, Guangzhou Medical University, Guangzhou, China[*1]Sino-French Hoffmann Institute of Immunology, College of Basic Medical Science, Guangzhou Medical University, Guangzhou, China
推荐引用方式(GB/T 7714)：
Li Ting,Liu Libao,Wu Hongling,et al.Anti-herpes simplex virus type 1 activity of Houttuynoid A, a flavonoid from Houttuynia cordata Thunb[J].ANTIVIRAL RESEARCH.2017,144:273-280.doi:10.1016/j.antiviral.2017.06.010.
APA：
Li, Ting,Liu, Libao,Wu, Hongling,Chen, Shaodan,Zhu, Qinchang...&Peng, Tao.(2017).Anti-herpes simplex virus type 1 activity of Houttuynoid A, a flavonoid from Houttuynia cordata Thunb.ANTIVIRAL RESEARCH,144,
MLA：
Li, Ting,et al."Anti-herpes simplex virus type 1 activity of Houttuynoid A, a flavonoid from Houttuynia cordata Thunb".ANTIVIRAL RESEARCH 144.(2017):273-280
