机构：[1]Center for Regenerative and Translational Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China广东省中医院[2]Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA[3]The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, People’s Republic of China深圳医学信息中心中国医学科学院阜外医院深圳医院
Human embryonic stem cells (hESCs) depend on glycolysis for energy supply and pluripotency and switch to oxidative phosphorylation upon differentiation. The underlying mechanisms remain unclear. Here, we demonstrate that indoleamine 2,3-dioxygenase 1 (IDO1) is expressed in primed hESCs and its expression rapidly downregulated upon hESC differentiation. IDO1 is required to maintain pluripotency by suppressing mitochondria activity and promoting glycolysis through the increase of NAD(+)/NADH ratio. The upregulation of IDO1 during hESC differentiation suppresses the differentiation of hESCs into certain lineages of cells such as cardiomyocytes, which depend on oxidative phosphorylation to satisfy their high energy demand. Therefore, IDO1 plays important roles in maintaining the pluripotency of hESCs. Stem Cells 2019;37:1158-1165
第一作者机构：[1]Center for Regenerative and Translational Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China[2]Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA
通讯作者：
通讯机构：[1]Center for Regenerative and Translational Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China[2]Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA[3]The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, People’s Republic of China[*1]The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, Guangdong, People’s Republic of China.[*2]Center for Regenerative and Translational Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510632, Guangdong, People’s Republic of China.
推荐引用方式(GB/T 7714)：
Liu Xin,Wang Meiyan,Jiang Tao,et al.IDO1 Maintains Pluripotency of Primed Human Embryonic Stem Cells by Promoting Glycolysis[J].STEM CELLS.2019,37(9):1158-1165.doi:10.1002/stem.3044.
APA：
Liu, Xin,Wang, Meiyan,Jiang, Tao,He, Jingjin,Fu, Xuemei&Xu, Yang.(2019).IDO1 Maintains Pluripotency of Primed Human Embryonic Stem Cells by Promoting Glycolysis.STEM CELLS,37,(9)
MLA：
Liu, Xin,et al."IDO1 Maintains Pluripotency of Primed Human Embryonic Stem Cells by Promoting Glycolysis".STEM CELLS 37..9(2019):1158-1165
